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    PRDM15 PR/SET domain 15 [ Homo sapiens (human) ]

    Gene ID: 63977, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PRDM15provided by HGNC
    Official Full Name
    PR/SET domain 15provided by HGNC
    Primary source
    HGNC:HGNC:13999
    See related
    Ensembl:ENSG00000141956 MIM:617692; AllianceGenome:HGNC:13999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PFM15; ZNF298; C21orf83
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 2.4), appendix (RPKM 1.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRDM15 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (41798225..41879344, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (40188592..40269664, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43218385..43299453, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43173001-43173792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43180486-43181120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43181121-43181755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43181756-43182390 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:43182391-43183024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43183726-43184325 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43184326-43184924 Neighboring gene microRNA 6814 Neighboring gene receptor interacting serine/threonine kinase 4 Neighboring gene uncharacterized LOC102724800 Neighboring gene Sharpr-MPRA regulatory region 172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43192149-43192696 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:43216480-43216980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18485 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43241376-43242575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43256373-43257080 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43274198-43275397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18493 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43318691-43319691 Neighboring gene C2 calcium dependent domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43364315-43364815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43370715-43371220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43373099-43373873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43378985-43379952 Neighboring gene small nucleolar RNA, H/ACA box 91 Neighboring gene NANOG hESC enhancer GRCh37_chr21:43388567-43389068 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:43415728-43415930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13336 Neighboring gene zinc finger and BTB domain containing 21 Neighboring gene ZNF295 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15. Zhao LN, et al. Int J Mol Sci, 2023 Jan 10. PMID 36674842, Free PMC Article
    2. PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary Disease in a Rural Population in Chile. Hosgood Iii HD, et al. Respiration, 2020. PMID 32222710
    3. Identification of a novel zinc finger protein gene (ZNF298) in the GAP2 of human chromosome 21q. Shibuya K, et al. Biochem Biophys Res Commun, 2005 Jul 1. PMID 15904895
    4. Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome. Mann N, et al. J Am Soc Nephrol, 2021 Mar. PMID 33593823, Free PMC Article
    5. The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression. Liu N, et al. J Exp Clin Cancer Res, 2023 Oct 11. PMID 37817227, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
      Title: The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
    2. Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15.
      Title: Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15.
    3. Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome.
      Title: Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome.
    4. PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary Disease in a Rural Population in Chile.
      Title: PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary Disease in a Rural Population in Chile.
    5. PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly.
      Title: PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly.
    6. Findings indicate that PR domain containing 15 protein (PRDM15) is important in both mouse and human induced pluripotent stem cells (iPSCs) reprogramming.
      Title: PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
    EBI GWAS Catalog
    Genome-wide association study of tanning phenotype in a population of European ancestry.
    EBI GWAS Catalog
    Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AP001619.2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PR domain zinc finger protein 15
    Names
    PR domain 15
    PR domain containing 15
    zinc finger protein 298

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040424.3 → NP_001035514.2  PR domain zinc finger protein 15 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks seven alternate in-frame exons and differs in the 3' UTR, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB051812, AP002955, HY066601
      Consensus CDS
      CCDS42932.2
      UniProtKB/TrEMBL
      E7ER26, E9PL97, Q6NXF8
      Related
      ENSP00000381556.2, ENST00000398548.6
      Conserved Domains (6) summary
      COG5048
      Location:363 → 825
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:692 → 712
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:628 → 649
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    2. NM_001282934.2 → NP_001269863.2  PR domain zinc finger protein 15 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks seven alternate in-frame exons, contains an alternate in-frame exon, and differs in the 3' UTR, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AP001619, AP002955, BC032305, HY066601
      Consensus CDS
      CCDS63370.2
      UniProtKB/TrEMBL
      Q6NXF8
      Related
      ENSP00000408592.2, ENST00000422911.6
      Conserved Domains (7) summary
      COG5048
      Location:676 → 845
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:712 → 732
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:648 → 669
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    3. NM_022115.7 → NP_071398.5  PR domain zinc finger protein 15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AB126081, AP001618, AP001619, AP002955
      Consensus CDS
      CCDS13676.2
      UniProtKB/TrEMBL
      Q6NXF8
      Related
      ENSP00000269844.4, ENST00000269844.5
      Conserved Domains (6) summary
      COG5048
      Location:429 → 891
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:758 → 778
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:694 → 715
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:107 → 232
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins
      NF033909
      Location:293 → 400
      opacity_OapA; opacity-associated protein OapA

    RNA

    1. NR_104257.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the internal exons and differs in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB051814, AB126081, AP002955
      Related
      ENST00000449395.6

    2. NR_104258.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains multiple differences in the internal exons and differs in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB051815, AB126081, AP002955
      Related
      ENST00000441787.5

    3. NR_104260.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains multiple differences, including use of an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB126081, AP001618, AP002955, AY063456, BC067102

    4. NR_135464.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains multiple differences, including use of an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF276513, AP002955, AY063456, BM544857, BM755202, CA949877, CF135664, CF137278, CF138151, CN400247, EC485279, HY003319, HY146343

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      41798225..41879344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440940.1 → XP_047296896.1  PR domain zinc finger protein 15 isoform X8

    2. XM_047440938.1 → XP_047296894.1  PR domain zinc finger protein 15 isoform X5

    3. XM_047440939.1 → XP_047296895.1  PR domain zinc finger protein 15 isoform X7

    4. XM_017028425.2 → XP_016883914.1  PR domain zinc finger protein 15 isoform X6

      UniProtKB/TrEMBL
      E7ER26, E9PL97, Q6NXF8
      Related
      ENSP00000431410.1, ENST00000447016.6
      Conserved Domains (6) summary
      COG5048
      Location:363 → 825
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:692 → 712
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:628 → 649
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    5. XM_047440937.1 → XP_047296893.1  PR domain zinc finger protein 15 isoform X4

    6. XM_011529675.2 → XP_011527977.1  PR domain zinc finger protein 15 isoform X3

      See identical proteins and their annotated locations for XP_011527977.1

      UniProtKB/TrEMBL
      Q6NXF8
      Conserved Domains (7) summary
      COG5048
      Location:676 → 845
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:712 → 732
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:648 → 669
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    7. XM_047440935.1 → XP_047296891.1  PR domain zinc finger protein 15 isoform X5

    8. XM_011529674.2 → XP_011527976.2  PR domain zinc finger protein 15 isoform X2

    9. XM_006724040.3 → XP_006724103.2  PR domain zinc finger protein 15 isoform X7

    10. XM_006724039.3 → XP_006724102.2  PR domain zinc finger protein 15 isoform X4

    11. XM_011529683.2 → XP_011527985.2  PR domain zinc finger protein 15 isoform X9

    12. XM_011529678.3 → XP_011527980.1  PR domain zinc finger protein 15 isoform X3

      See identical proteins and their annotated locations for XP_011527980.1

      UniProtKB/TrEMBL
      Q6NXF8
      Conserved Domains (7) summary
      COG5048
      Location:676 → 845
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:712 → 732
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:648 → 669
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    13. XM_011529681.4 → XP_011527983.1  PR domain zinc finger protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011527983.1

      UniProtKB/TrEMBL
      Q6NXF8
      Conserved Domains (7) summary
      smart00317
      Location:53 → 169
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:367 → 820
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:716 → 736
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:652 → 673
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:376 → 398
      zf-C2H2; Zinc finger, C2H2 type
      pfam06217
      Location:219 → 284
      GAGA_bind; GAGA binding protein-like family
      pfam13465
      Location:728 → 753
      zf-H2C2_2; Zinc-finger double domain

    14. XM_011529676.3 → XP_011527978.1  PR domain zinc finger protein 15 isoform X3

      See identical proteins and their annotated locations for XP_011527978.1

      UniProtKB/TrEMBL
      Q6NXF8
      Conserved Domains (7) summary
      COG5048
      Location:676 → 845
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:712 → 732
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:648 → 669
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    15. XM_047440936.1 → XP_047296892.1  PR domain zinc finger protein 15 isoform X6

      UniProtKB/TrEMBL
      E7ER26, E9PL97

    16. XM_011529677.3 → XP_011527979.1  PR domain zinc finger protein 15 isoform X3

      See identical proteins and their annotated locations for XP_011527979.1

      UniProtKB/TrEMBL
      Q6NXF8
      Conserved Domains (7) summary
      COG5048
      Location:676 → 845
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:712 → 732
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:648 → 669
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    17. XM_011529679.3 → XP_011527981.1  PR domain zinc finger protein 15 isoform X3

      See identical proteins and their annotated locations for XP_011527981.1

      UniProtKB/TrEMBL
      Q6NXF8
      Conserved Domains (7) summary
      COG5048
      Location:676 → 845
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:712 → 732
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:648 → 669
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam16031
      Location:227 → 310
      TonB_N; TonB N-terminal region
      pfam18445
      Location:12 → 37
      zf_PR_Knuckle; PR zinc knuckle motif
      cd19199
      Location:41 → 166
      PR-SET_PRDM15; PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins

    RNA

    1. XR_007067792.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      40188592..40269664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324753.1 → XP_054180728.1  PR domain zinc finger protein 15 isoform X8

    2. XM_054324751.1 → XP_054180726.1  PR domain zinc finger protein 15 isoform X5

    3. XM_054324752.1 → XP_054180727.1  PR domain zinc finger protein 15 isoform X7

    4. XM_054324747.1 → XP_054180722.1  PR domain zinc finger protein 15 isoform X6

    5. XM_054324750.1 → XP_054180725.1  PR domain zinc finger protein 15 isoform X4

    6. XM_054324740.1 → XP_054180715.1  PR domain zinc finger protein 15 isoform X3

    7. XM_054324746.1 → XP_054180721.1  PR domain zinc finger protein 15 isoform X5

    8. XM_054324739.1 → XP_054180714.1  PR domain zinc finger protein 15 isoform X2

    9. XM_054324749.1 → XP_054180724.1  PR domain zinc finger protein 15 isoform X7

    10. XM_054324745.1 → XP_054180720.1  PR domain zinc finger protein 15 isoform X4

    11. XM_054324754.1 → XP_054180729.1  PR domain zinc finger protein 15 isoform X9

    12. XM_054324743.1 → XP_054180718.1  PR domain zinc finger protein 15 isoform X3

    13. XM_054324738.1 → XP_054180713.1  PR domain zinc finger protein 15 isoform X1

    14. XM_054324742.1 → XP_054180717.1  PR domain zinc finger protein 15 isoform X3

    15. XM_054324748.1 → XP_054180723.1  PR domain zinc finger protein 15 isoform X6

    16. XM_054324741.1 → XP_054180716.1  PR domain zinc finger protein 15 isoform X3

    17. XM_054324744.1 → XP_054180719.1  PR domain zinc finger protein 15 isoform X3

    RNA

    1. XR_008485343.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57071.4 GenPept UniProtKB/Swiss-Prot:P57071

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