Vmn2r116 vomeronasal 2, receptor 116 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vmn2r116provided by MGI
Official Full Name: vomeronasal 2, receptor 116provided by MGI
Primary source: MGI:MGI:3646674
See related: Ensembl:ENSMUSG00000090966 AllianceGenome:MGI:3646674
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V2Rp5; EG619697
Summary: Enables pheromone receptor activity. Acts upstream of or within positive regulation of female receptivity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 17 A3.3; 17 11.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (23603777..23620838)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23384803..23401864)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

charge-charge interactions determine the specificity of ESP1 binding to V2Rp5 in the large extracellular region characteristic of class C GPCRs.
Title: Structure of the mouse sex peptide pheromone ESP1 reveals a molecular basis for specific binding to the class C G-protein-coupled vomeronasal receptor.
ESP1 is recognized by a specific vomeronasal receptor, V2Rp5, and the ligand-receptor interaction results in sex-specific signal transmission to the amygdaloid and hypothalamic nuclei via the accessory olfactory bulb
Title: The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pheromone receptor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of female receptivity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vomeronasal type-2 receptor 116

Names: vomeronasal 2 receptor p5; vomeronasal receptor Vmn2r116; vomeronasal type-2 receptor P5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104580.1 → NP_001098050.1 vomeronasal type-2 receptor 116 precursor

See identical proteins and their annotated locations for NP_001098050.1

Status: PROVISIONAL

Source sequence(s)

CT485617

Consensus CDS

CCDS50009.1

UniProtKB/Swiss-Prot

D7URW5, E9Q6I0

UniProtKB/TrEMBL

A0A3Q4EG82

Related

ENSMUSP00000128106.2, ENSMUST00000164856.3

Conserved Domains (3) summary

cd15283
Location:584 → 835

7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06365
Location:41 → 503

PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam07562
Location:511 → 564

NCD3G; Nine Cysteines Domain of family 3 GPCR