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    BDNF brain derived neurotrophic factor [ Bos taurus (domestic cattle) ]

    Gene ID: 617701, updated on 10-Oct-2024

    Summary

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    Official Symbol
    BDNFprovided by VGNC
    Official Full Name
    brain derived neurotrophic factorprovided by VGNC
    Primary source
    VGNC:VGNC:26461
    See related
    BGD:BT12389; Ensembl:ENSBTAG00000008134
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BDNF in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (58382886..58445297, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing G protein-coupled receptor 4 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component Neighboring gene uncharacterized LOC132342349 Neighboring gene kinesin family member 18A Neighboring gene transfer RNA cysteine (anticodon ACA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene encoding bovine brain-derived neurotrophic factor (BDNF). Arab SF, et al. Gene, 1997 Jan 31. PMID 9034318
    2. The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm. Li C, et al. Theriogenology, 2012 Feb. PMID 22015157
    3. Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. Ulrich R, et al. Vet Pathol, 2008 May. PMID 18487493
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.
      Title: The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm.
    2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
      Title: Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133995

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nerve growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brain-derived neurotrophic factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046607.2 → NP_001040072.1  brain-derived neurotrophic factor precursor

      See identical proteins and their annotated locations for NP_001040072.1

      Status: PROVISIONAL

      Source sequence(s)
      BC109860
      UniProtKB/Swiss-Prot
      Q32KY2, Q95106
      UniProtKB/TrEMBL
      A0AAA9SHE4
      Related
      ENSBTAP00000010694.5, ENSBTAT00000010694.7
      Conserved Domains (1) summary
      smart00140
      Location:136 → 243
      NGF; Nerve growth factor (NGF or beta-NGF)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      58382886..58445297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216334.5 → XP_005216391.1  brain-derived neurotrophic factor isoform X1

      See identical proteins and their annotated locations for XP_005216391.1

      UniProtKB/TrEMBL
      A0AAA9SHE4, A0AAA9T573
      Related
      ENSBTAP00000091690.1, ENSBTAT00000123593.1
      Conserved Domains (1) summary
      smart00140
      Location:144 → 251
      NGF; Nerve growth factor (NGF or beta-NGF)

    2. XM_059874987.1 → XP_059730970.1  brain-derived neurotrophic factor isoform X2

      UniProtKB/Swiss-Prot
      Q32KY2, Q95106

    3. XM_005216335.5 → XP_005216392.1  brain-derived neurotrophic factor isoform X2

      See identical proteins and their annotated locations for XP_005216392.1

      UniProtKB/Swiss-Prot
      Q32KY2, Q95106
      UniProtKB/TrEMBL
      A0AAA9SHE4
      Related
      ENSBTAP00000078080.1, ENSBTAT00000124916.1
      Conserved Domains (1) summary
      smart00140
      Location:136 → 243
      NGF; Nerve growth factor (NGF or beta-NGF)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95106.2 GenPept UniProtKB/Swiss-Prot:Q95106

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.