U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Max MYC associated factor X [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60661, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Maxprovided by RGD
    Official Full Name
    MYC associated factor Xprovided by RGD
    Primary source
    RGD:621101
    See related
    EnsemblRapid:ENSRNOG00000008049 AllianceGenome:RGD:621101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of gene expression; and response to insulin. Located in PML body and dendrite. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 71.3), Spleen (RPKM 70.0) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Max in Genome Data Viewer
    Location:
    6q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (101369989..101395333, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95636859..95662204, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99984260..100011460, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene RAB15, member RAS oncogene family Neighboring gene farnesyltransferase, CAAX box, subunit beta Neighboring gene ribosomal protein S7, pseudogene 24 Neighboring gene uncharacterized LOC134479401

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration. Lani-Louzada R, et al. Invest Ophthalmol Vis Sci, 2022 Feb 1. PMID 35103748, Free PMC Article
    2. The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max. Hopewell R, et al. Mol Cell Biol, 1995 Jul. PMID 7791753, Free PMC Article
    3. Molecular cloning and sequencing of rat Max cDNA: castration-induced expression of the 2 kb transcript in male accessory sex organs of rats. Izawa M. Biochim Biophys Acta, 1993 Dec 14. PMID 8268234
    4. Involvement of c-myc and max in CNS beta-endorphin modulation of hepatic ornithine decarboxylase responsiveness to insulin in rat pups. Bartolome JV, et al. Life Sci, 1999. PMID 10072196
    5. Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage. Petrs-Silva H, et al. Exp Neurol, 2008 Sep. PMID 18601921

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration.
      Title: Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration.
    2. The positive rate of Max expression was significantly lower in ductal adenocarcinoma in the control group.
      Title: [Expression of RAD51 and MAX in pancreatic cancer rats].
    3. Proteosomal degradation of nuclear Max coupled with continued expression and cytoplasmic accumulation of Max, with blockade of nucleocytoplasmic transport of the newly synthesized protein, is an early event after CNS axonal damage.
      Title: Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage.
    4. Maximal glucose-induced expression of the L-PK gene in INS-1-derived 832/13 cells involves increased c-Myc abundance, recruitment of c-Myc, Max, and ChREBP to the promoter.
      Title: c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells.
    5. The regulation of Max content during liver development and its potential role in determining c-Myc localization are means by which Max may control the biological activity of the c-Myc/Max/Mad network during liver development.
      Title: Coordinated regulation of c-Myc and Max in rat liver development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC124611

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron apoptotic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to axon injury IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in retina development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Mad-Max complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Myc-Max complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein max
    Names
    myc-associated factor X

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411963.1 → NP_001398892.1  protein max isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HCC5

    2. NM_022210.2 → NP_071546.1  protein max isoform 1

      See identical proteins and their annotated locations for NP_071546.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P52164
      UniProtKB/TrEMBL
      A6HCC6
      Related
      ENSRNOP00000086002.1, ENSRNOT00000106817.2
      Conserved Domains (1) summary
      cd11406
      Location:24 → 92
      bHLHzip_Max; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins

    RNA

    1. NR_177987.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    2. NR_177988.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NR_177989.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOT00000107085.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      101369989..101395333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262440.1 → XP_063118510.1  protein max isoform X1

    2. XM_063262442.1 → XP_063118512.1  protein max isoform X3

    3. XM_063262441.1 → XP_063118511.1  protein max isoform X2

      Related
      ENSRNOP00000010954.5, ENSRNOT00000010954.7

    RNA

    1. XR_593084.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52164.1 GenPept UniProtKB/Swiss-Prot:P52164

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous