Ecel1 endothelin converting enzyme-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ecel1provided by RGD
Official Full Name: endothelin converting enzyme-like 1provided by RGD
Primary source: RGD:61806
See related: EnsemblRapid:ENSRNOG00000019447 AllianceGenome:RGD:61806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dine
Summary: Predicted to enable metalloendopeptidase activity. Involved in intracellular signal transduction and neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 7.0), Testes (RPKM 0.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (95267417..95276508, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87819516..87829154, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (94238568..94252484, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the requisite synergistic effect in neuronal injury through DINE neuronal injury-inducible gene
Title: Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons.
Damage-induced neuronal endopeptidase play an important role in embryonic neural development, in particular in peripheral ganglia derived from the neural crest, and in some neurons from the basal plate such as the hypothalamus and cranial motor neurons.
Title: Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system.
DINE gene expression is regulated separately by both LIF and NGF deprivation, and this regulation pattern is similar to that of galanin gene expression after nerve injury
Title: Damage-induced neuronal endopeptidase (DINE/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury.

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General gene information

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Markers

RH144119 (e-PCR)
- UniSTS:233365

AW527169 (e-PCR)
- UniSTS:246003

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in respiratory system process	IEA Inferred from Electronic Annotation more info
involved_in respiratory system process	ISO Inferred from Sequence Orthology more info
involved_in respiratory system process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: endothelin-converting enzyme-like 1

Names: damage-induced neuronal endopeptidase; metallopeptidase; xce protein

NP_068544.2

EC 3.4.24.11

XP_017452104.1

EC 3.4.24.11

XP_063123735.1

EC 3.4.24.11

XP_063123736.1

EC 3.4.24.11

XP_063123737.1

EC 3.4.24.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021776.3 → NP_068544.2 endothelin-converting enzyme-like 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9JHL3, Q9Z192

UniProtKB/TrEMBL

A6JWK8, D4AD32

Related

ENSRNOP00000095212.1, ENSRNOT00000095466.2

Conserved Domains (1) summary

cd08662
Location:121 → 773

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

95267417..95276508 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267666.1 → XP_063123736.1 endothelin-converting enzyme-like 1 isoform X1
XM_063267665.1 → XP_063123735.1 endothelin-converting enzyme-like 1 isoform X1
XM_017596615.3 → XP_017452104.1 endothelin-converting enzyme-like 1 isoform X2

UniProtKB/Swiss-Prot

Q9JHL3, Q9Z192

UniProtKB/TrEMBL

A6JWK8, D4AD32

Conserved Domains (1) summary

cd08662
Location:121 → 773

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
XM_063267667.1 → XP_063123737.1 endothelin-converting enzyme-like 1 isoform X1