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    Prom1 prominin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60357, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prom1provided by RGD
    Official Full Name
    prominin 1provided by RGD
    Primary source
    RGD:69367
    See related
    EnsemblRapid:ENSRNOG00000003098 AllianceGenome:RGD:69367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prom; CD133
    Summary
    Predicted to enable actinin binding activity; cadherin binding activity; and cholesterol binding activity. Predicted to be involved in several processes, including glomerular epithelial cell differentiation; photoreceptor cell maintenance; and retina morphogenesis in camera-type eye. Predicted to be located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; and photoreceptor outer segment membrane. Predicted to be active in several cellular components, including apical plasma membrane; microvillus; and prominosome. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 250.8), Kidney (RPKM 151.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prom1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71202303..71307008)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (66989545..67094534)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71532321..71637400)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane anterior posterior transformation 1 Neighboring gene uncharacterized LOC120096623 Neighboring gene U7 small nuclear RNA Neighboring gene fibroblast growth factor binding protein 1 Neighboring gene APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondria transfer via tunneling nanotubes is an important mechanism by which CD133+ scattered tubular cells eliminate hypoxic tubular cell injury. Zou X, et al. Biochem Biophys Res Commun, 2020 Jan 29. PMID 31759629
    2. CD133+ hepatic stellate cells are progenitor cells. Kordes C, et al. Biochem Biophys Res Commun, 2007 Jan 12. PMID 17118341
    3. Pentaspan membrane glycoprotein, prominin-1, is involved in glucose metabolism and cytoskeleton alteration. Yang C, et al. Biochemistry (Mosc), 2007 Aug. PMID 17922643
    4. Prominin-1 glycosylation changes throughout early pregnancy in uterine epithelial cells under the influence of maternal ovarian hormones. Dowland SN, et al. Reprod Fertil Dev, 2017 Jun. PMID 27166505
    5. Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Weigmann A, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356465, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?
      Title: High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?
    2. Mitochondria transfer via tunneling nanotubes is an important mechanism by which CD133+ scattered tubular cells eliminate hypoxic tubular cell injury.
      Title: Mitochondria transfer via tunneling nanotubes is an important mechanism by which CD133+ scattered tubular cells eliminate hypoxic tubular cell injury.
    3. The here presented data revealed the upregulation of retinal tissue levels and immunoreactivity of VEGFA and prom1 during hyperglycemia that could contribute to the development of diabetic vasculopathy and neuropathy.
      Title: Hyperglycemia Alters the Protein Levels of Prominin-1 and VEGFA in the Retina of Albino Rats.
    4. Data suggest that, at fertilization, Prom1 (97-kDa core protein and 147-/120-kDa glycoforms) is located diffusely in apical domain of UECs (uterine epithelial cells); at implantation, Prom1 is concentrated toward APM (apical plasma membrane) with down-regulation of 120-kDa glycoform and up-regulation of 97-kDa core protein.
      Title: Prominin-1 glycosylation changes throughout early pregnancy in uterine epithelial cells under the influence of maternal ovarian hormones.
    5. Their potential to differentiate into endothelial or hepatocyte lineages suggests important functions of CD133+ HSC during liver regeneration.
      Title: CD133+ hepatic stellate cells are progenitor cells.
    6. After ischemia/reperfusion injury in kidney, the expression rates of CD133 and KIM-1 antigen rise obviously in cortex renis.
      Title: [Influence and distribution of CD133 and CD34 antigen expression in proximal tubule epithelial cells during ischemia/reperfusion injury in rats].
    7. We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
      Title: Novel hepatic progenitor cell surface markers in the adult rat liver.
    8. Adenovirus-mediated stromal cell-derived- factor-1alpha gene transfer induces cardiac preservation after infarction via angiogenesis of CD133+ stem cells and anti-apoptosis.
      Title: Adenovirus-mediated stromal cell-derived- factor-1alpha gene transfer induces cardiac preservation after infarction via angiogenesis of CD133+ stem cells and anti-apoptosis.
    9. prominin-1 is involved in glucose metabolism and may regulate cellular glucose through its effect on cytoskeleton.
      Title: Pentaspan membrane glycoprotein, prominin-1, is involved in glucose metabolism and cytoskeleton alteration.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156650

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actinin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in camera-type eye photoreceptor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in camera-type eye photoreceptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glomerular parietal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in podocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nephron tubule epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in prominosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prominosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prominin-1
    Names
    fudenine

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110137.1 → NP_001103607.1  prominin-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001103607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AY262731, BI286840, CB780214, EV765242
      UniProtKB/TrEMBL
      Q7TSL4
      Conserved Domains (1) summary
      pfam05478
      Location:18 → 812
      Prominin

    2. NM_021751.2 → NP_068519.2  prominin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_068519.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF386758, BI286840, CB780214
      UniProtKB/TrEMBL
      A0A8I5ZQT1, F7FI74, Q91XN5
      Conserved Domains (1) summary
      pfam05478
      Location:18 → 812
      Prominin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      71202303..71307008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092362.2 → XP_038948290.1  prominin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWD0, A0A8I5ZQT1
      Conserved Domains (1) summary
      pfam05478
      Location:18 → 821
      Prominin

    2. XM_063273554.1 → XP_063129624.1  prominin-1 isoform X14

    3. XM_063273536.1 → XP_063129606.1  prominin-1 isoform X3

      UniProtKB/TrEMBL
      F7FI74, Q91XN5

    4. XM_063273549.1 → XP_063129619.1  prominin-1 isoform X11

      Related
      ENSRNOP00000071297.2, ENSRNOT00000082592.3

    5. XM_063273541.1 → XP_063129611.1  prominin-1 isoform X7

    6. XM_063273550.1 → XP_063129620.1  prominin-1 isoform X12

    7. XM_008770211.4 → XP_008768433.1  prominin-1 isoform X1

      See identical proteins and their annotated locations for XP_008768433.1

      UniProtKB/TrEMBL
      A0A0G2JWD0, A0A8I5ZQT1
      Conserved Domains (1) summary
      pfam05478
      Location:18 → 821
      Prominin

    8. XM_063273538.1 → XP_063129608.1  prominin-1 isoform X6

    9. XM_063273535.1 → XP_063129605.1  prominin-1 isoform X2

    10. XM_063273542.1 → XP_063129612.1  prominin-1 isoform X8

    11. XM_039092365.2 → XP_038948293.1  prominin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQT1
      Conserved Domains (1) summary
      pfam05478
      Location:18 → 805
      Prominin

    12. XM_063273537.1 → XP_063129607.1  prominin-1 isoform X5

    13. XM_063273551.1 → XP_063129621.1  prominin-1 isoform X13

    14. XM_063273552.1 → XP_063129622.1  prominin-1 isoform X14

    15. XM_063273544.1 → XP_063129614.1  prominin-1 isoform X9

    16. XM_063273547.1 → XP_063129617.1  prominin-1 isoform X11

    17. XM_063273539.1 → XP_063129609.1  prominin-1 isoform X7

      Related
      ENSRNOP00000004231.8, ENSRNOT00000004231.8

    18. XM_063273543.1 → XP_063129613.1  prominin-1 isoform X8

    19. XM_039092364.2 → XP_038948292.1  prominin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQT1, F7FI74, Q91XN5
      Related
      ENSRNOP00000080859.2, ENSRNOT00000113497.2
      Conserved Domains (1) summary
      pfam05478
      Location:18 → 812
      Prominin

    20. XM_063273545.1 → XP_063129615.1  prominin-1 isoform X9

      Related
      ENSRNOP00000068615.3, ENSRNOT00000084322.3

    21. XM_063273548.1 → XP_063129618.1  prominin-1 isoform X11

      Related
      ENSRNOP00000097023.1, ENSRNOT00000118243.2

    22. XM_063273553.1 → XP_063129623.1  prominin-1 isoform X14

      Related
      ENSRNOP00000110983.1, ENSRNOT00000163101.1

    23. XM_039092361.2 → XP_038948289.1  prominin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWD0, A0A8I5ZQT1
      Related
      ENSRNOP00000069832.1, ENSRNOT00000083701.3
      Conserved Domains (1) summary
      pfam05478
      Location:18 → 821
      Prominin

    24. XM_063273540.1 → XP_063129610.1  prominin-1 isoform X7

    25. XM_063273546.1 → XP_063129616.1  prominin-1 isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version

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