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    Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60341, updated on 2-Nov-2024

    Summary

    Official Symbol
    Camkk1provided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase kinase 1provided by RGD
    Primary source
    RGD:62023
    See related
    EnsemblRapid:ENSRNOG00000018242 AllianceGenome:RGD:62023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in activation of protein kinase activity. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 166.6), Lung (RPKM 59.6) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Camkk1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58135872..58159023)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57637335..57660498)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59585023..59608180)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Neighboring gene purinergic receptor P2X 1 Neighboring gene nuclear cap binding subunit 3 Neighboring gene integrin subunit alpha E Neighboring gene histone H3 associated protein kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium/calmodulin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase kinase 1
    Names
    alpha CaMKK
    caM-KK 1
    caM-KK alpha
    caM-kinase IV kinase
    caM-kinase kinase 1
    caM-kinase kinase alpha
    caMKK 1
    caMKK alpha
    calcium/calmodulin-dependent protein kinase kinase 1, alpha
    calcium/calmodulin-dependent protein kinase kinase alpha
    NP_113850.1
    XP_006246861.1
    XP_006246863.1
    XP_008766088.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031662.1NP_113850.1  calcium/calmodulin-dependent protein kinase kinase 1

      See identical proteins and their annotated locations for NP_113850.1

      Status: PROVISIONAL

      Source sequence(s)
      AB023658
      UniProtKB/Swiss-Prot
      P97756, Q64572, Q794E3
      UniProtKB/TrEMBL
      A0A8I5YBZ4
      Related
      ENSRNOP00000091768.2, ENSRNOT00000106120.2
      Conserved Domains (2) summary
      smart00220
      Location:128409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:127410
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      58135872..58159023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767866.4XP_008766088.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_008766088.1

      UniProtKB/TrEMBL
      A0A8I5YBZ4, A6HGH7
      Related
      ENSRNOP00000076910.2, ENSRNOT00000104077.2
      Conserved Domains (1) summary
      cd14200
      Location:127410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
    2. XM_006246799.5XP_006246861.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006246861.1

      UniProtKB/TrEMBL
      A0A8I5YBZ4, A6HGH7
      Conserved Domains (1) summary
      cd14200
      Location:127410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
    3. XM_006246801.5XP_006246863.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006246863.1

      UniProtKB/TrEMBL
      A0A8I5YBZ4, A6HGH7
      Conserved Domains (1) summary
      cd14200
      Location:127410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1