Epb41l1 erythrocyte membrane protein band 4.1-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Epb41l1provided by RGD
Full Name: erythrocyte membrane protein band 4.1-like 1provided by RGD
Primary source: RGD:71087
See related: EnsemblRapid:ENSRNOG00000057817 AllianceGenome:RGD:71087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 4.1N; Epb4.1l1
Summary: Enables signaling receptor binding activity. Predicted to be involved in actomyosin structure organization and regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane. Located in synaptic membrane. Part of protein-containing complex. Is active in parallel fiber to Purkinje cell synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 11. Orthologous to human EPB41L1 (erythrocyte membrane protein band 4.1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 375.4), Adrenal (RPKM 169.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (165389295..165512821)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144929195..145052723)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (152492725..152622047)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis
Title: Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis.
Type I inositol 1,4,5-trisphosphate receptor (IP3R1) localization via protein 4.1N is necessary for divalent calcium ion wave (Ca2+) formation, which in turn mediates neurite formation.
Title: The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves.
study describes a previously unknown mechanism that governs activity-dependent GluR1 trafficking, reveals an interaction between AMPAR palmitoylation and phosphorylation, and underscores the importance of 4.1N in AMPAR trafficking and synaptic plasticity.
Title: Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation.
4.1N was expressed postsynaptically at the climbing fibers synapse at early ages during Purkinje cell dendritic growth; its expression changed from neurons to Bergmann glia once these glial cells had completed their enwrapping process.
Title: Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1N during rat cerebellar development.
the finding that interactions between protein 4.1N and the 1,4,5-trisphosphate receptor vary among cell types may provide an additional, tissue-specific mechanism to shape the pattern of Ca2+ waves.
Title: Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line.
4.1N serves as a linker protein between IP3R1 and actin filaments.
Title: Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129967 (e-PCR)
- UniSTS:213255

WI-22026 (e-PCR)
- UniSTS:74324

EPB41L1 (e-PCR)
- UniSTS:505948

MARC_15779-15780:1017948347:1 (e-PCR)
- UniSTS:267901

MARC_15779-15780:1033152668:24 (e-PCR)
- UniSTS:267901

D3Got117 (e-PCR)
- UniSTS:114307

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: band 4.1-like protein 1

Names: band 4.1-like protein 1-like; erythrocyte protein band 4.1-like 1; neuronal protein 4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021681.3 → NP_067713.2 band 4.1-like protein 1 isoform L

See identical proteins and their annotated locations for NP_067713.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (L).

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2K0F3, D3ZMI4

Related

ENSRNOP00000071420.1, ENSRNOT00000089719.3

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:1412 → 1537

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
NM_172090.4 → NP_742087.1 band 4.1-like protein 1 isoform S

See identical proteins and their annotated locations for NP_742087.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform S, which is shorter than isoform L.

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9WTP0, Q9WTP1

UniProtKB/TrEMBL

A6KIB0, D4A9L5

Related

ENSRNOP00000071845.4, ENSRNOT00000080543.4

Conserved Domains (7) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam00373
Location:183 → 288

FERM_M; FERM central domain

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:741 → 866

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 425

FA; FERM adjacent (FA)

pfam09379
Location:101 → 164

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

165389295..165512821

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284435.1 → XP_063140505.1 band 4.1-like protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K0F3
XM_017592007.3 → XP_017447496.1 band 4.1-like protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K0F3, D3ZMI4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:1412 → 1537

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
XM_017592006.3 → XP_017447495.1 band 4.1-like protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K0F3, D3ZMI4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:1412 → 1537

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
XM_017592010.3 → XP_017447499.1 band 4.1-like protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K0F3, D3ZMI4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:1412 → 1537

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
XM_063284445.1 → XP_063140515.1 band 4.1-like protein 1 isoform X14
XM_017592005.3 → XP_017447494.1 band 4.1-like protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K0F3, D3ZMI4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:1412 → 1537

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
XM_063284436.1 → XP_063140506.1 band 4.1-like protein 1 isoform X8

UniProtKB/Swiss-Prot

Q9WTP0, Q9WTP1

UniProtKB/TrEMBL

A6KIB0

Related

ENSRNOP00000072128.4, ENSRNOT00000087289.4
XM_063284442.1 → XP_063140512.1 band 4.1-like protein 1 isoform X12
XM_063284440.1 → XP_063140510.1 band 4.1-like protein 1 isoform X10

UniProtKB/TrEMBL

A0A0G2K0B2, A6KIB1

Related

ENSRNOP00000071375.2, ENSRNOT00000085938.4
XM_063284444.1 → XP_063140514.1 band 4.1-like protein 1 isoform X14
XM_063284446.1 → XP_063140516.1 band 4.1-like protein 1 isoform X15
XM_008762381.4 → XP_008760603.1 band 4.1-like protein 1 isoform X3

See identical proteins and their annotated locations for XP_008760603.1

UniProtKB/TrEMBL

A0A0G2K0F3, D3ZMI4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:1412 → 1537

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
XM_063284438.1 → XP_063140508.1 band 4.1-like protein 1 isoform X10

UniProtKB/TrEMBL

A0A0G2K0B2, A6KIB1
XM_063284443.1 → XP_063140513.1 band 4.1-like protein 1 isoform X14
XM_063284437.1 → XP_063140507.1 band 4.1-like protein 1 isoform X9
XM_063284441.1 → XP_063140511.1 band 4.1-like protein 1 isoform X11

Related

ENSRNOP00000074285.4, ENSRNOT00000087907.4
XM_063284447.1 → XP_063140517.1 band 4.1-like protein 1 isoform X15
XM_039105759.1 → XP_038961687.1 band 4.1-like protein 1 isoform X6

UniProtKB/TrEMBL

D3ZMI4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:1428 → 1481

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
XM_017592011.1 → XP_017447500.1 band 4.1-like protein 1 isoform X5

UniProtKB/TrEMBL

D3ZMI4
XM_017592012.1 → XP_017447501.1 band 4.1-like protein 1 isoform X7

UniProtKB/TrEMBL

D4A9L5
XM_039105762.1 → XP_038961690.1 band 4.1-like protein 1 isoform X13

UniProtKB/TrEMBL

D4A9L5, D4ACZ4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:493 → 524

SAB; SAB domain

pfam05902
Location:606 → 730

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)
XM_017592004.1 → XP_017447493.1 band 4.1-like protein 1 isoform X2

UniProtKB/TrEMBL

D3ZMI4
XM_063284448.1 → XP_063140518.1 band 4.1-like protein 1 isoform X16
XM_017592003.1 → XP_017447492.1 band 4.1-like protein 1 isoform X1

UniProtKB/TrEMBL

D3ZMI4
XM_039105757.1 → XP_038961685.1 band 4.1-like protein 1 isoform X4

UniProtKB/TrEMBL

D3ZMI4

Conserved Domains (5) summary

smart00295
Location:98 → 288

B41; Band 4.1 homologues

cd13184
Location:283 → 376

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:474 → 504

SAB; SAB domain

pfam05902
Location:1394 → 1518

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:385 → 428

FA; FERM adjacent (FA)