Ramp1 receptor activity modifying protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ramp1provided by RGD
Official Full Name: receptor activity modifying protein 1provided by RGD
Primary source: RGD:61870
See related: EnsemblRapid:ENSRNOG00000089232 AllianceGenome:RGD:61870
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables coreceptor activity. Involved in receptor internalization. Located in extracellular space. Is active in glutamatergic synapse and synaptic membrane. Orthologous to human RAMP1 (receptor activity modifying protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 297.6), Muscle (RPKM 83.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (99213031..99263696)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (91765481..91816152)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (98313632..98364206)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia.
Title: Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.
After traumatic injury to periodontal ligament, CGRP nerve fibers appear in close vicinity of small and large receptor activity modifying protein (RAMP)1 cells at 5-7 days.
Title: Increase of CGRP-containing nerve fibers in the rat periodontal ligament after luxation.
The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion.
Title: Calcitonin gene-related peptide and its receptor components in the human sphenopalatine ganglion -- interaction with the sensory system.
Data demonstrate that there is a rich expression of calcitonin gene-related peptide (CGRP) and its receptor elements CLR and RAMP1 in the cerebellum which points towards a functional role of CGRP in cerebellar Purkinje cells.
Title: Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat.
ADM peptide concentration exhibited a spatio-temporal pattern in the rat female reproductive system during gestation and this suggests that ADM may play important roles in gestation.
Title: Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation.
Effects of immobilization on tendon healing were related to changes in the peripheral expression of substance P (NK(1))- and calcitonin gene-related peptide (CRLR and RAMP-1)- receptors
Title: Joint immobilization reduces the expression of sensory neuropeptide receptors and impairs healing after tendon rupture in a rat model.
RAMP interaction with the CTRa in COS-7 or HEK-293 cells leads to selective modulation of signaling pathways activated by the receptor complex.
Title: Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors.
changes in RAMP1 activity are involved in the pathophysiology of L-DOPA induced dyskinesia.
Title: Receptor-activity modifying protein 1 expression is increased in the striatum following repeated L-DOPA administration in a 6-hydroxydopamine lesioned rat model of Parkinson's disease.
RAMP1 immunoreactivity (-ir) was found within arterial blood vessels, mononuclear cells, and Schwann cells in dura mater and in CGRP neurons in trigeminal ganglia
Title: Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distribution.
These findings suggest that CGRP or adrenomedullin receptors modulate opioid release in the dorsal horn.
Title: Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables amylin receptor activity	IEA Inferred from Electronic Annotation more info
enables amylin receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide binding	IEA Inferred from Electronic Annotation more info
enables calcitonin gene-related peptide binding	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin gene-related peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables coreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables coreceptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in amylin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcitonin gene-related peptide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcitonin gene-related peptide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CGRP receptor complex	IEA Inferred from Electronic Annotation more info
part_of CGRP receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor activity-modifying protein 1

Names: receptor (G protein-coupled) activity modifying protein 1; receptor (calcitonin) activity modifying protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031645.1 → NP_113833.1 receptor activity-modifying protein 1 precursor

See identical proteins and their annotated locations for NP_113833.1

Status: PROVISIONAL

Source sequence(s)

AB042887

UniProtKB/Swiss-Prot

Q9JJ74

UniProtKB/TrEMBL

A6JQP8, Q9JMD9

Related

ENSRNOP00000104056.1, ENSRNOT00000122624.1

Conserved Domains (1) summary

pfam04901
Location:37 → 145

RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

99213031..99263696

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084148.2 → XP_038940076.1 receptor activity-modifying protein 1 isoform X2

Conserved Domains (1) summary

pfam04901
Location:38 → 64

RAMP; Receptor activity modifying family
XM_063267661.1 → XP_063123731.1 receptor activity-modifying protein 1 isoform X2
XM_017596613.3 → XP_017452102.1 receptor activity-modifying protein 1 isoform X1

UniProtKB/TrEMBL

A0A8L2QEF6

Conserved Domains (1) summary

pfam04901
Location:16 → 123

RAMP; Receptor activity modifying family