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    Cpq carboxypeptidase Q [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58952, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Cpqprovided by RGD
    Official Full Name
    carboxypeptidase Qprovided by RGD
    Primary source
    RGD:628610
    See related
    EnsemblRapid:ENSRNOG00000005931 AllianceGenome:RGD:628610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LAL; Pgcp; lal-1
    Summary
    Predicted to enable metallodipeptidase activity and protein homodimerization activity. Involved in proteolysis; thyroid hormone generation; and tissue regeneration. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and lysosome. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 886.6), Liver (RPKM 660.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpq in Genome Data Viewer
    Location:
    7q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (66148973..66719189)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (64264025..64830867)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (71709174..72167413)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479601 Neighboring gene syndecan 2 Neighboring gene translationally-controlled tumor protein pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene TSPY-like 5 Neighboring gene spermatogenesis associated 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin. Suban D, et al. Biochimie, 2012 Mar. PMID 22127294
    2. lal-1: a differentially expressed novel gene during proliferation in liver regeneration and in hepatoma cells. Della Fazia MA, et al. Genes Cells, 2002 Nov. PMID 12390252
    3. Purification and primary structure determination of human lysosomal dipeptidase. Dolenc I, et al. Biol Chem, 2003 Feb. PMID 12675526
    4. Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl-alpha-glutamate carboxypeptidase/prostate-specific membrane antigen. Gingras R, et al. J Biol Chem, 1999 Apr 23. PMID 10206990
    5. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lal-1 is involved in liver regeneration and its expression is finely regulated during proliferative process {Liver Annexin Like-1 (lal-1)
      Title: lal-1: a differentially expressed novel gene during proliferation in liver regeneration and in hepatoma cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallodipeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone generation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase Q
    Names
    hematopoietic lineage switch 2 related protein
    hls2-rp
    liver annexin like-1
    liver annexin-like protein 1
    plasma glutamate carboxypeptidase
    NP_113828.1
    XP_008763639.1
    XP_038935736.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031640.1 → NP_113828.1  carboxypeptidase Q precursor

      See identical proteins and their annotated locations for NP_113828.1

      Status: PROVISIONAL

      Source sequence(s)
      AF097723
      UniProtKB/TrEMBL
      A0A8I6AKX5
      Related
      ENSRNOP00000008211.4, ENSRNOT00000008211.8
      Conserved Domains (2) summary
      cd03883
      Location:47 → 449
      M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
      cd04815
      Location:130 → 256
      PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      66148973..66719189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765417.4 → XP_008763639.1  carboxypeptidase Q isoform X1

      See identical proteins and their annotated locations for XP_008763639.1

      UniProtKB/Swiss-Prot
      Q6IRK9, Q9JLV0, Q9Z1Y1
      UniProtKB/TrEMBL
      A0A8I6AKX5, A6HQY8
      Conserved Domains (1) summary
      cd03883
      Location:42 → 449
      M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase

    2. XM_039079808.2 → XP_038935736.1  carboxypeptidase Q isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKX5
      Related
      ENSRNOP00000108968.1, ENSRNOT00000159568.1
      Conserved Domains (1) summary
      cd03883
      Location:42 → 435
      M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IRK9.1 GenPept UniProtKB/Swiss-Prot:Q6IRK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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