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    MOK MOK protein kinase [ Homo sapiens (human) ]

    Gene ID: 5891, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MOKprovided by HGNC
    Official Full Name
    MOK protein kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:9833
    See related
    Ensembl:ENSG00000080823 MIM:605762; AllianceGenome:HGNC:9833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAGE; RAGE1; STK30; RAGE-1
    Summary
    This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
    Expression
    Broad expression in testis (RPKM 9.4), thyroid (RPKM 2.1) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MOK in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102214596..102305164, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96451049..96540765, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102690778..102771501, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102550057-102551256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6109 Neighboring gene heat shock protein 90 alpha family class A member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6110 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102605474-102605669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102622168-102623084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102623085-102624001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102625184-102625684 Neighboring gene WD repeat domain 20 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:102638165-102639150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102650679-102651180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102651181-102651680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6111 Neighboring gene uncharacterized LOC105370677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102780520-102781020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9070 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene zinc finger protein 839

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. Gaugler B, et al. Immunogenetics, 1996. PMID 8781117
    2. mRNA expression of tumor-associated antigens in melanoma tissues and cell lines. Eichmüller S, et al. Exp Dermatol, 2002 Aug. PMID 12190937
    3. Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes. Götte K, et al. Acta Otolaryngol, 2002 Jul. PMID 12206267
    4. Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas. Yan M, et al. Appl Immunohistochem Mol Morphol, 2003 Jun. PMID 12777992
    5. MOK overexpression is associated with promoter hypomethylation in patients with acute myeloid leukemia. Qian J, et al. Int J Clin Exp Pathol, 2015. PMID 25755699, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAGE silencing deters CML-AGE induced inflammation and TLR4 expression in endothelial cells.
      Title: RAGE silencing deters CML-AGE induced inflammation and TLR4 expression in endothelial cells.
    2. our results suggest MOK promoter hypomethylation is a common event and contributes to MOK overexpression in acute myeloid leukemia
      Title: MOK overexpression is associated with promoter hypomethylation in patients with acute myeloid leukemia.
    3. The findings indicate a statistically significant association of p.Gly82Ser polymorphism in RAGE with DR in T2DM patients.
      Title: Association of RAGE (p.Gly82Ser) and MnSOD (p.Val16Ala) polymorphisms with diabetic retinopathy in T2DM patients from north India.
    4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
      Title: Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity.
    5. Our results suggest that RAGE may be important in tumor invasion and could be a potential predictor for the prognosis of hepatocellular carcinoma patients.
      Title: Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma.
    6. PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups.
      Title: TLR4 and RAGE: similar routes leading to inflammation in type 2 diabetic patients.
    7. The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B.
      Title: S100B attenuates microglia activation in gliomas: possible role of STAT3 pathway.
    8. POLL is under genetic selection in Sub-Saharan African populations.
      Title: Targeted resequencing of two genes, RAGE and POLL, confirms findings from a genome-wide scan for adaptive evolution and provides evidence for positive selection in additional populations.
    9. Compared RAGE and PAX-2 staining in metastatic clear renal cell carcinoma.
      Title: The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma marker.
    10. RAGE was demonstrated in all 8 yolk sac tumors and 21 of 26 embryonal carcinomas. In yolk sac tumors, RAGE reactivity was diffusely present throughout the tumors. In embryonal carcinomas, RAGE was identified only in yolk sac components
      Title: Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16778

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary base ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MAPK/MAK/MRK overlapping kinase
    Names
    renal cell carcinoma antigen
    renal tumor antigen 1
    NP_001258940.1
    NP_001317163.1
    NP_001340756.1
    NP_001340757.1
    NP_001340758.1
    NP_001340759.1
    NP_001340760.1
    NP_001340761.1
    NP_055041.1
    XP_006720289.1
    XP_016877045.1
    XP_016877046.1
    XP_016877047.1
    XP_047287599.1
    XP_047287600.1
    XP_047287601.1
    XP_047287602.1
    XP_047287603.1
    XP_047287604.1
    XP_047287605.1
    XP_047287606.1
    XP_054232495.1
    XP_054232496.1
    XP_054232497.1
    XP_054232498.1
    XP_054232499.1
    XP_054232500.1
    XP_054232501.1
    XP_054232502.1
    XP_054232503.1
    XP_054232504.1
    XP_054232505.1
    XP_054232506.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272011.2 → NP_001258940.1  MAPK/MAK/MRK overlapping kinase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB022694, AK302349, AL359402, DB517173
      Consensus CDS
      CCDS61552.1
      UniProtKB/Swiss-Prot
      Q9UQ07
      Related
      ENSP00000428942.1, ENST00000524214.5
      Conserved Domains (2) summary
      smart00220
      Location:4 → 255
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07831
      Location:4 → 255
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    2. NM_001330234.2 → NP_001317163.1  MAPK/MAK/MRK overlapping kinase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402, DB517173
      Consensus CDS
      CCDS81854.1
      UniProtKB/Swiss-Prot
      Q9UQ07
      Related
      ENSP00000429469.1, ENST00000522874.5

    3. NM_001353827.2 → NP_001340756.1  MAPK/MAK/MRK overlapping kinase isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402
      Conserved Domains (1) summary
      cd07831
      Location:4 → 254
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    4. NM_001353828.2 → NP_001340757.1  MAPK/MAK/MRK overlapping kinase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402
      Conserved Domains (1) summary
      cl21453
      Location:1 → 221
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001353829.2 → NP_001340758.1  MAPK/MAK/MRK overlapping kinase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402
      Conserved Domains (1) summary
      cl21453
      Location:1 → 180
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001353830.2 → NP_001340759.1  MAPK/MAK/MRK overlapping kinase isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402
      Conserved Domains (1) summary
      cl21453
      Location:1 → 179
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001353831.2 → NP_001340760.1  MAPK/MAK/MRK overlapping kinase isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402
      UniProtKB/TrEMBL
      Q49A77
      Conserved Domains (1) summary
      cl21453
      Location:1 → 103
      PKc_like; Protein Kinases, catalytic domain

    8. NM_001353832.2 → NP_001340761.1  MAPK/MAK/MRK overlapping kinase isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402
      Conserved Domains (2) summary
      COG0515
      Location:2 → 135
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:1 → 51
      PKc_like; Protein Kinases, catalytic domain

    9. NM_014226.3 → NP_055041.1  MAPK/MAK/MRK overlapping kinase isoform 1

      See identical proteins and their annotated locations for NP_055041.1

      Status: REVIEWED

      Source sequence(s)
      AB022694, DB037795, DB517173
      Consensus CDS
      CCDS9971.1
      UniProtKB/Swiss-Prot
      B2R6Z4, B7Z7P6, E7ER76, E7ERR8, Q92790, Q93067, Q9UQ07
      Related
      ENSP00000355304.2, ENST00000361847.7
      Conserved Domains (2) summary
      smart00220
      Location:4 → 285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07831
      Location:4 → 285
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    RNA

    1. NR_073540.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI932404, AL359402, U46193, U46194
      Related
      ENST00000559138.5

    2. NR_073541.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      U46193
      Related
      ENST00000517966.5

    3. NR_073542.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' exon structure and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the longest open reading frame is in a different frame compared to variant 1, and there is no support for the predicted protein encoded by this ORF.
      Source sequence(s)
      DB517173, U46192, U46193
      Related
      ENST00000524370.5

    4. NR_073543.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BG184866, DB517173, U46191, U46193
      Related
      ENST00000523231.5

    5. NR_148552.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL352978, AL359402

    6. NR_148553.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI932404, AL352978, AL359402

    7. NR_148554.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI932404, AL352978, AL359402

    8. NR_148555.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI932404, AL352978, AL359402

    9. NR_148556.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI932404, AL352978, AL359402

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102214596..102305164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431647.1 → XP_047287603.1  MAPK/MAK/MRK overlapping kinase isoform X8

    2. XM_047431646.1 → XP_047287602.1  MAPK/MAK/MRK overlapping kinase isoform X6

    3. XM_017021556.3 → XP_016877045.1  MAPK/MAK/MRK overlapping kinase isoform X4

    4. XM_017021558.2 → XP_016877047.1  MAPK/MAK/MRK overlapping kinase isoform X9

    5. XM_017021557.3 → XP_016877046.1  MAPK/MAK/MRK overlapping kinase isoform X7

    6. XM_047431644.1 → XP_047287600.1  MAPK/MAK/MRK overlapping kinase isoform X3

    7. XM_006720226.4 → XP_006720289.1  MAPK/MAK/MRK overlapping kinase isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:4 → 285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07831
      Location:4 → 285
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    8. XM_047431643.1 → XP_047287599.1  MAPK/MAK/MRK overlapping kinase isoform X1

    9. XM_047431645.1 → XP_047287601.1  MAPK/MAK/MRK overlapping kinase isoform X5

    10. XM_047431650.1 → XP_047287606.1  MAPK/MAK/MRK overlapping kinase isoform X12

    11. XM_047431649.1 → XP_047287605.1  MAPK/MAK/MRK overlapping kinase isoform X11

    12. XM_047431648.1 → XP_047287604.1  MAPK/MAK/MRK overlapping kinase isoform X10

    RNA

    1. XR_007064041.1 RNA Sequence

    2. XR_007064040.1 RNA Sequence

    3. XR_007064039.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      96451049..96540765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376527.1 → XP_054232502.1  MAPK/MAK/MRK overlapping kinase isoform X8

    2. XM_054376525.1 → XP_054232500.1  MAPK/MAK/MRK overlapping kinase isoform X6

    3. XM_054376523.1 → XP_054232498.1  MAPK/MAK/MRK overlapping kinase isoform X4

    4. XM_054376524.1 → XP_054232499.1  MAPK/MAK/MRK overlapping kinase isoform X5

    5. XM_054376531.1 → XP_054232506.1  MAPK/MAK/MRK overlapping kinase isoform X12

    6. XM_054376528.1 → XP_054232503.1  MAPK/MAK/MRK overlapping kinase isoform X9

    7. XM_054376526.1 → XP_054232501.1  MAPK/MAK/MRK overlapping kinase isoform X7

    8. XM_054376522.1 → XP_054232497.1  MAPK/MAK/MRK overlapping kinase isoform X3

    9. XM_054376521.1 → XP_054232496.1  MAPK/MAK/MRK overlapping kinase isoform X2

    10. XM_054376520.1 → XP_054232495.1  MAPK/MAK/MRK overlapping kinase isoform X1

    11. XM_054376530.1 → XP_054232505.1  MAPK/MAK/MRK overlapping kinase isoform X11

    12. XM_054376529.1 → XP_054232504.1  MAPK/MAK/MRK overlapping kinase isoform X10

    RNA

    1. XR_008488890.1 RNA Sequence

    2. XR_008488889.1 RNA Sequence

    3. XR_008488888.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UQ07.1 GenPept UniProtKB/Swiss-Prot:Q9UQ07

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