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    Slco1c1 solute carrier organic anion transporter family, member 1c1 [ Mus musculus (house mouse) ]

    Gene ID: 58807, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slco1c1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 1c1provided by MGI
    Primary source
    MGI:MGI:1889679
    See related
    Ensembl:ENSMUSG00000030235 AllianceGenome:MGI:1889679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oatp2; Oatpf; OATP-F; OATP-14; Slc21a14
    Summary
    Predicted to enable bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Predicted to be involved in several processes, including positive regulation of thyroid hormone generation; sodium-independent organic anion transport; and thyroid hormone transport. Located in basolateral plasma membrane. Is expressed in blood vessel; central nervous system; cochlea; and retina. Orthologous to human SLCO1C1 (solute carrier organic anion transporter family member 1C1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 12.2), cortex adult (RPKM 11.8) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slco1c1 in Genome Data Viewer
    Location:
    6 G2; 6 72.38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141470080..141515903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141524354..141570177)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A, cGMP inhibited Neighboring gene STARR-seq mESC enhancer starr_17689 Neighboring gene predicted gene 10400 Neighboring gene STARR-seq mESC enhancer starr_17690 Neighboring gene STARR-seq mESC enhancer starr_17691 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17693 Neighboring gene STARR-seq mESC enhancer starr_17694 Neighboring gene solute carrier organic anion transporter family, member 1b2 Neighboring gene STARR-seq mESC enhancer starr_17695 Neighboring gene solute carrier organic anion transporter family, member 1a7 Neighboring gene STARR-seq mESC enhancer starr_17696 Neighboring gene STARR-seq mESC enhancer starr_17697

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes. Schnell C, et al. Brain Struct Funct, 2015 Jan. PMID 24129767, Free PMC Article
    2. Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Tohyama K, et al. Endocrinology, 2004 Sep. PMID 15166123
    3. Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function. Siemes D, et al. Cells, 2023 Oct 19. PMID 37887331, Free PMC Article
    4. Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice. Chen J, et al. Int J Mol Sci, 2023 Feb 9. PMID 36834863, Free PMC Article
    5. Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Mayerl S, et al. Endocrinology, 2012 Mar. PMID 22294745

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
      Title: Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
    2. Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
      Title: Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
    3. Our data provide solid evidence for a unique gate-keeper function of MCT8 and OATP1C1 in SC activation, underscoring the importance of a finely tuned TH signaling during myogenesis.
      Title: Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.
    4. This study identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex
      Title: The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.
    5. The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.
      Title: Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.
    6. Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
      Title: Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
    7. SLCO1C1 is expressed in the neuronal cell lineage during brain development. Expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia.
      Title: A transgenic approach to identify thyroxine transporter-expressing structures in brain development.
    8. expression of candidate thyroid hormone transporters Lat1, Mct8, Mct10, and Oatp1c1 in mouse cochlear development
      Title: Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea.
    9. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.
      Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.
    10. basolateral localization of mOatp14 in the choroid plexus in which it may also play a role in T4 uptake.
      Title: Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90655

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyroid hormone transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thyroid hormone transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 1C1
    Names
    organic anion transporter 2
    organic anion transporter F
    organic anion-transporting polypeptide 14
    solute carrier family 21 (organic anion transporter), member 14
    thyroxine transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177772.2 → NP_001171243.1  solute carrier organic anion transporter family member 1C1 isoform 2

      See identical proteins and their annotated locations for NP_001171243.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC153834, AC155835
      UniProtKB/TrEMBL
      A0A0N4SUZ6
      Conserved Domains (3) summary
      cd06174
      Location:46 → 302
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:475 → 528
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44 → 640
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    2. NM_021471.3 → NP_067446.1  solute carrier organic anion transporter family member 1C1 isoform 1

      See identical proteins and their annotated locations for NP_067446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC153834, AC155835
      Consensus CDS
      CCDS20677.1
      UniProtKB/Swiss-Prot
      Q8BX54, Q9ERB5
      UniProtKB/TrEMBL
      A0A0N4SUZ6
      Related
      ENSMUSP00000032362.10, ENSMUST00000032362.12
      Conserved Domains (3) summary
      cd06174
      Location:46 → 302
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:475 → 528
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44 → 641
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RNA

    1. NR_149743.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate, frame-shifting splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the canonical translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153834, AC155835
      Related
      ENSMUST00000135562.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      141470080..141515903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERB5.1 GenPept UniProtKB/Swiss-Prot:Q9ERB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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