NGB neuroglobin [Homo sapiens (human)] - Gene

Summary

Official Symbol: NGBprovided by HGNC
Official Full Name: neuroglobinprovided by HGNC
Primary source: HGNC:HGNC:14077
See related: Ensembl:ENSG00000165553 MIM:605304; AllianceGenome:HGNC:14077
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Expression: Biased expression in adrenal (RPKM 4.2), brain (RPKM 1.8) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q24.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (77265483..77271206, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (71474790..71480551, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (77731826..77737549, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prognostic Values Serum Cav-1 and NGB Levels in Early Neurological Deterioration After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke.
Title: Prognostic Values Serum Cav-1 and NGB Levels in Early Neurological Deterioration After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke.
Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis.
Title: Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis.
Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells.
Title: Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells.
Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer.
Title: Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer.
Conversion of Human Neuroglobin into a Multifunctional Peroxidase by Rational Design.
Title: Conversion of Human Neuroglobin into a Multifunctional Peroxidase by Rational Design.
Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells.
Title: Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells.
Neuroglobin and mitochondria: The impact on neurodegenerative diseases.
Title: Neuroglobin and mitochondria: The impact on neurodegenerative diseases.
Early stage neuroglobin level as a predictor of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage.
Title: Early stage neuroglobin level as a predictor of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage.
A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
Title: A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
Neuroglobin As Key Mediator in the 17beta-Estradiol-Induced Antioxidant Cell Response to Oxidative Stress.
Title: Neuroglobin As Key Mediator in the 17β-Estradiol-Induced Antioxidant Cell Response to Oxidative Stress.

Submit: New GeneRIF Correction See all GeneRIFs (96)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S693E (e-PCR)
- UniSTS:151573

D14S1234 (e-PCR)
- UniSTS:25658

NGB (e-PCR)
- UniSTS:511983

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitrite reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxygen transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxygen transport	NAS Non-traceable Author Statement more info	PubMed
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuroglobin

Names: nitrite reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.