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    Lair1 leukocyte-associated immunoglobulin-like receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 574531, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Lair1provided by RGD
    Official Full Name
    leukocyte-associated immunoglobulin-like receptor 1provided by RGD
    Primary source
    RGD:1560048
    See related
    EnsemblRapid:ENSRNOG00000027733 AllianceGenome:RGD:1560048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in immune response-regulating signaling pathway. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 15.4), Kidney (RPKM 12.8) and 8 other tissues See more
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    Genomic context

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    See Lair1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (79140850..79261546)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (70068571..70187851)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73752192..73870421)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene leukocyte receptor cluster member 8 Neighboring gene tweety family member 1 Neighboring gene uncharacterized LOC134482886 Neighboring gene uncharacterized LOC134484886

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the rat homologue of LAIR-1. Lebbink RJ, et al. Immunogenetics, 2005 Jun. PMID 15902436
    2. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion. Peng DH, et al. Nat Commun, 2020 Sep 9. PMID 32908154, Free PMC Article
    3. Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Hoelsbrekken SE, et al. Immunogenetics, 2005 Aug. PMID 16041585
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.
      Title: Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte-associated immunoglobulin-like receptor 1
    Names
    LAIR-1
    leukocyte-associated Ig-like receptor 1
    rLAIR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029928.1 → NP_001025099.1  leukocyte-associated immunoglobulin-like receptor 1 precursor

      See identical proteins and their annotated locations for NP_001025099.1

      Status: PROVISIONAL

      Source sequence(s)
      AY863023
      UniProtKB/Swiss-Prot
      P0C1X9
      UniProtKB/TrEMBL
      A6KNI4
      Related
      ENSRNOP00000037815.4, ENSRNOT00000036413.6
      Conserved Domains (1) summary
      cl11960
      Location:30 → 115
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      79140850..79261546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272104.1 → XP_063128174.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X2

    2. XM_017589623.3 → XP_017445112.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P0C1X9
      UniProtKB/TrEMBL
      A6KNI4
      Conserved Domains (1) summary
      cl11960
      Location:30 → 115
      Ig; Immunoglobulin domain

    3. XM_017589620.3 → XP_017445109.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P0C1X9
      UniProtKB/TrEMBL
      A6KNI4
      Conserved Domains (1) summary
      cl11960
      Location:30 → 115
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C1X9.1 GenPept UniProtKB/Swiss-Prot:P0C1X9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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