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    GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 [ Homo sapiens (human) ]

    Gene ID: 57452, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GALNT16provided by HGNC
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 16provided by HGNC
    Primary source
    HGNC:HGNC:23233
    See related
    Ensembl:ENSG00000100626 MIM:615132; AllianceGenome:HGNC:23233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GALNTL1; GALNACT16; GalNAc-T16
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 7.7), heart (RPKM 6.0) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GALNT16 in Genome Data Viewer
    Location:
    14q24.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (69259631..69386337)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (63472675..63600865)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69726875..69823759)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2739 Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene DEAD-box helicase 18 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 12367 Neighboring gene Sharpr-MPRA regulatory region 6895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5878 Neighboring gene GALNT16 and EXD2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5879 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:69705439-69706063 Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5880 Neighboring gene uncharacterized LOC105370549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69800956-69801456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69801457-69801957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69815418-69815918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8636 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69864016-69864524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69864525-69865032 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:69865025-69865265 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:69865234-69866433 Neighboring gene solute carrier family 39 member 9 Neighboring gene ERH mRNA splicing and mitosis factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5881 Neighboring gene pleckstrin homology and coiled-coil domain containing D1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Evaluation of GALNT16 polymorphisms to breast cancer risk in Chinese population. Wu H, et al. Mol Genet Genomic Med, 2019 Aug. PMID 31286696, Free PMC Article
    2. Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK. Peng C, et al. J Exp Clin Cancer Res, 2021 Aug 27. PMID 34452628, Free PMC Article
    3. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Raman J, et al. Glycobiology, 2012 Jun. PMID 22186971, Free PMC Article
    4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. Hirosawa M, et al. DNA Res, 1999 Oct 29. PMID 10574461
    5. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Ito T, et al. Nat Genet, 2021 Dec. PMID 34857952

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK.
      Title: Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK.
    2. rs2105269 and rs72625676 were associated with higher breast cancer (BC) risk in younger patients with age </=51. For rs1275678 polymorphism, there was a significantly decreased risk of BC among older patients. rs2105269 was associated with tumor size and lymph node metastasis. Study suggests that GALNT16 polymorphisms are associated with BC susceptibility in Chinese population.
      Title: Evaluation of GALNT16 polymorphisms to breast cancer risk in Chinese population.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1130, MGC141855

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via serine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation via threonine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 16
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
    galNAc-T-like protein 1
    polypeptide GalNAc transferase 16
    polypeptide GalNAc transferase-like protein 1
    polypeptide N-acetylgalactosaminyltransferase-like protein 1
    pp-GaNTase-like protein 1
    protein-UDP acetylgalactosaminyltransferase-like protein 1
    putative polypeptide N-acetylgalactosaminyltransferase-like protein 1
    NP_001161840.1
    NP_065743.2
    XP_011535308.1
    XP_011535309.1
    XP_016876987.1
    XP_047287574.1
    XP_054232422.1
    XP_054232423.1
    XP_054232424.1
    XP_054232425.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168368.2 → NP_001161840.1  polypeptide N-acetylgalactosaminyltransferase 16

      See identical proteins and their annotated locations for NP_001161840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK091426, AK289745, AL157996, AL359317, DA493083
      Consensus CDS
      CCDS32107.1
      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8
      Related
      ENSP00000402970.3, ENST00000448469.8
      Conserved Domains (2) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:441 → 543
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_020692.3 → NP_065743.2  polypeptide N-acetylgalactosaminyltransferase 16

      See identical proteins and their annotated locations for NP_065743.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL157996, AL359317, BC098578, BG059801, DA493083
      Consensus CDS
      CCDS32107.1
      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8
      Related
      ENSP00000336729.4, ENST00000337827.8
      Conserved Domains (2) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:441 → 543
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      69259631..69386337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021498.2 → XP_016876987.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8
      Conserved Domains (2) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:441 → 543
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. XM_047431618.1 → XP_047287574.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8
      Related
      ENSP00000451200.1, ENST00000553669.1

    3. XM_011537006.4 → XP_011535308.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

      See identical proteins and their annotated locations for XP_011535308.1

      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8
      Conserved Domains (2) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:441 → 543
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    4. XM_011537007.4 → XP_011535309.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X2

      Related
      ENSP00000451420.1, ENST00000553471.6
      Conserved Domains (3) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:126 → 222
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:441 → 514
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    RNA

    1. XR_007064036.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      63472675..63600865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376447.1 → XP_054232422.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8

    2. XM_054376449.1 → XP_054232424.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8

    3. XM_054376448.1 → XP_054232423.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q4KMG3, Q58A55, Q8N428, Q9ULT9
      UniProtKB/TrEMBL
      Q68VJ8

    4. XM_054376450.1 → XP_054232425.1  polypeptide N-acetylgalactosaminyltransferase 16 isoform X2

    RNA

    1. XR_008488885.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N428.2 GenPept UniProtKB/Swiss-Prot:Q8N428

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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