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    Phax phosphorylated adaptor for RNA export [ Mus musculus (house mouse) ]

    Gene ID: 56698, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Phaxprovided by MGI
    Official Full Name
    phosphorylated adaptor for RNA exportprovided by MGI
    Primary source
    MGI:MGI:1891839
    See related
    Ensembl:ENSMUSG00000008301 AllianceGenome:MGI:1891839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p55; Rnuxa; D18Ertd65e; 2810055C14Rik; 4933427L19Rik
    Summary
    Predicted to enable mRNA cap binding complex binding activity and toxic substance binding activity. Acts upstream of or within snRNA export from nucleus. Located in cytoplasm and nucleus. Orthologous to human PHAX (phosphorylated adaptor for RNA export). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 28.4), CNS E18 (RPKM 25.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phax in Genome Data Viewer
    Location:
    18 D3; 18 30.63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56695641..56720784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56562569..56587712)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene aldehyde dehydrogenase family 7, member A1 Neighboring gene STARR-seq mESC enhancer starr_44664 Neighboring gene microRNA 1258 Neighboring gene sperm microtubule inner protein 10 Neighboring gene predicted gene, 50288 Neighboring gene STARR-seq mESC enhancer starr_44668 Neighboring gene STARR-positive B cell enhancer ABC_E5662 Neighboring gene predicted gene, 41738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export. Segref A, et al. RNA, 2001 Mar. PMID 11333016, Free PMC Article
    2. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Ohno M, et al. Cell, 2000 Apr 14. PMID 10786834
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA cap binding complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA cap binding complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables toxic substance binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within snRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylated adapter RNA export protein
    Names
    RNA U small nuclear RNA export adapter protein
    RNA U, small nuclear RNA export adaptor
    phosphorylation regulated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162989.1 → NP_001156461.1  phosphorylated adapter RNA export protein isoform 2

      See identical proteins and their annotated locations for NP_001156461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK012949, AK016958, BC049590
      Consensus CDS
      CCDS50292.1
      UniProtKB/TrEMBL
      G5E8V8
      Related
      ENSMUSP00000122948.2, ENSMUST00000130163.8
      Conserved Domains (1) summary
      pfam10258
      Location:199 → 282
      RNA_GG_bind; PHAX RNA-binding domain

    2. NM_019996.4 → NP_064380.3  phosphorylated adapter RNA export protein isoform 1

      See identical proteins and their annotated locations for NP_064380.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK012949, BC049590, CJ157832
      Consensus CDS
      CCDS29259.1
      UniProtKB/Swiss-Prot
      Q8BSR8, Q9JJT9
      UniProtKB/TrEMBL
      A0PJ63
      Related
      ENSMUSP00000008445.6, ENSMUST00000008445.7
      Conserved Domains (1) summary
      pfam10258
      Location:221 → 304
      RNA_GG_bind; PHAX RNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      56695641..56720784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJT9.1 GenPept UniProtKB/Swiss-Prot:Q9JJT9

    Gene LinkOut

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