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    angptl6 angiopoietin-like 6 [ Danio rerio (zebrafish) ]

    Gene ID: 561927, updated on 2-Nov-2024

    Summary

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    Official Symbol
    angptl6provided by ZNC
    Official Full Name
    angiopoietin-like 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9735
    See related
    Ensembl:ENSDARG00000020265 AllianceGenome:ZFIN:ZDB-GENE-030131-9735
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb242; sb:cb242
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including digestive system; immune system; pectoral fin bud; tail bud; and yolk syncytial layer. Orthologous to human ANGPTL6 (angiopoietin like 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See angptl6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (54524226..54550668, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54269624..54296069, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10a Neighboring gene si:ch73-208g10.1 Neighboring gene peter pan homolog Neighboring gene purinergic receptor P2Y11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish. Kubota Y, et al. Gene Expr Patterns, 2005 Jun. PMID 15939380
    2. Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Anderson RM, et al. Dev Biol, 2009 Oct 1. PMID 19631206, Free PMC Article
    3. DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. Liu X, et al. J Hematol Oncol, 2015 Feb 22. PMID 25886310, Free PMC Article
    4. setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Liu DJ, et al. Cell Discov, 2020. PMID 33088589, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. developmental expression of Angptl1, 2 and 6 in zebrafish
      Title: Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-related protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014821.1 → NP_001014821.1  angiopoietin-related protein 6 precursor

      See identical proteins and their annotated locations for NP_001014821.1

      Status: PROVISIONAL

      Source sequence(s)
      AB199649
      UniProtKB/TrEMBL
      Q5KQT8
      Related
      ENSDARP00000022066.5, ENSDART00000018044.8
      Conserved Domains (3) summary
      cd00087
      Location:274 → 488
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam07798
      Location:46 → 150
      DUF1640; Protein of unknown function (DUF1640)
      cl23887
      Location:126 → 230
      DUF4349; Domain of unknown function (DUF4349)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      54524226..54550668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299794.4 → XP_009298069.1  angiopoietin-related protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B1B3, F1R2V2
      Conserved Domains (3) summary
      cd00087
      Location:274 → 488
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam07798
      Location:46 → 150
      DUF1640; Protein of unknown function (DUF1640)
      cl23720
      Location:95 → 209
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein Strain
    Heading Accession and Version

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