Srcin1 SRC kinase signaling inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srcin1provided by RGD
Official Full Name: SRC kinase signaling inhibitor 1provided by RGD
Primary source: RGD:708439
See related: EnsemblRapid:ENSRNOG00000011475 AllianceGenome:RGD:708439
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P140; Snip; p140Cap
Summary: Enables protein domain specific binding activity. Involved in negative regulation of protein secretion. Located in several cellular components, including filopodium; lamellipodium; and postsynaptic density. Is active in postsynapse and presynapse. Orthologous to human SRCIN1 (SRC kinase signaling inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 68.0), Testes (RPKM 43.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (82999295..83066359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (82502911..82569882, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (85460059..85517671, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of miR-150 promoted angiogenesis and proliferation of endothelial progenitor cells by targeting SRCIN1 in vitro and thrombus resolution in vivo.
Title: MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1.
Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex.
Title: A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
we here demonstrate that p140Cap is a key element for both learning and synaptic plasticity
Title: p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.
Possible involvement of p140Cap in insulin secretion; the reduction of p140Cap might be related to abnormal insulin secretion in diabetes mellitus.
Title: Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats.
Data show that p140Cap suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility.
Title: p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation.
These results suggest that p140Cap is involved in neurotransmitter release, synapse formation/maintenance, and signaling.
Title: Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d10mgh5 (e-PCR)
- UniSTS:120622

D10Mco32 (e-PCR)
- UniSTS:240208

D10Mco33 (e-PCR)
- UniSTS:240209

D10RAT144 (e-PCR)
- UniSTS:120659

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
NOT located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SRC kinase signaling inhibitor 1

Names: SNAP25-interacting protein; p130Cas-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393740.2 → NP_001380669.1 SRC kinase signaling inhibitor 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AEP4

Related

ENSRNOP00000083677.2, ENSRNOT00000108672.2

Conserved Domains (2) summary

smart00806
Location:218 → 289

AIP3; Actin interacting protein 3

TIGR02169
Location:719 → 873

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
NM_001393741.2 → NP_001380670.1 SRC kinase signaling inhibitor 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AEP4, A6HIK5

Related

ENSRNOP00000099638.1, ENSRNOT00000153078.1

Conserved Domains (2) summary

TIGR02169
Location:720 → 874

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam03915
Location:219 → 316

AIP3; Actin interacting protein 3
NM_019378.3 → NP_062251.1 SRC kinase signaling inhibitor 1 isoform 2

See identical proteins and their annotated locations for NP_062251.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9QXY2, Q9QXY3

UniProtKB/TrEMBL

A0A8I6AEP4, A6HIK6

Conserved Domains (1) summary

pfam03915
Location:219 → 290

AIP3; Actin interacting protein 3