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    PRH2 proline rich protein HaeIII subfamily 2 [ Homo sapiens (human) ]

    Gene ID: 5555, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PRH2provided by HGNC
    Official Full Name
    proline rich protein HaeIII subfamily 2provided by HGNC
    Primary source
    HGNC:HGNC:9367
    See related
    Ensembl:ENSG00000134551 MIM:168790; AllianceGenome:HGNC:9367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Pr; pr1/Pr2; PRP-1/PRP-2
    Summary
    This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]
    Expression
    Restricted expression toward salivary gland (RPKM 6639.8) See more
    Orthologs
    all
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    Genomic context

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    See PRH2 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10929236..10934845)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10782594..10807884)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11081835..11087444)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene Sharpr-MPRA regulatory region 13514 Neighboring gene taste 2 receptor member 12 pseudogene Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene taste 2 receptor member 13 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:11094509-11095708 Neighboring gene taste 2 receptor member 14 Neighboring gene taste 2 receptor member 15 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Complete covalent structure of a proline-rich phosphoprotein, PRP-2, an inhibitor of calcium phosphate crystal growth from human parotid saliva. Schlesinger DH, et al. Int J Pept Protein Res, 1986 Apr. PMID 3710693
    2. Localization of the human salivary protein complex (SPC) to chromosome band 12p13.2. Mamula PW, et al. Cytogenet Cell Genet, 1985. PMID 4053693
    3. Primary structure of the active tryptic fragments of human and monkey salivary anionic proline-rich proteins. Schlesinger DH, et al. Int J Pept Protein Res, 1981 Jan. PMID 7228490
    4. The primary structure of a salivary calcium-binding proline-rich phosphoprotein (protein C), a possible precursor of a related salivary protein A. Wong RS, et al. J Biol Chem, 1980 Jun 25. PMID 7380845
    5. The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation to a salivary proline-rich phosphoprotein, protein C. Isemura S, et al. J Biochem, 1980 Apr. PMID 7390979

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries.
      Title: Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries.
    2. We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous bacteria match and predict individual differences in the development of caries..They instead developed 3.9-fold more caries than P1 children from plaque accumulation in general when treated with orthodontic multibrackets; and had basic PRP polymorphisms and low DMBT1-mediated S. mutans adhesion
      Title: Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686B01256, DKFZp686F14256, DKFZp686I11251, DKFZp686J06255, DKFZp686L01253, DKFZp686L16244, DKFZp686M04243, DKFZp686N24248

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    salivary acidic proline-rich phosphoprotein 1/2
    Names
    acidic salivary proline-rich protein, HaeIII type, 2
    parotid acidic protein
    parotid double-band protein
    parotid proline-rich protein 1/2
    protein C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110213.1 → NP_001103683.1  salivary acidic proline-rich phosphoprotein 1/2 preproprotein

      See identical proteins and their annotated locations for NP_001103683.1

      Status: REVIEWED

      Source sequence(s)
      AC006518, BC095488, BX648656
      Consensus CDS
      CCDS8636.1
      UniProtKB/Swiss-Prot
      A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6
      Related
      ENSP00000379682.3, ENST00000396400.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10929236..10934845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429101.1 → XP_047285057.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

      UniProtKB/Swiss-Prot
      A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6
      Related
      ENSP00000371271.3, ENST00000381847.7

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      108262..133551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329620.1 → XP_054185595.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

      UniProtKB/Swiss-Prot
      A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

    2. XM_054329621.1 → XP_054185596.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

      UniProtKB/Swiss-Prot
      A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      108262..133551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329988.1 → XP_054185963.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

      UniProtKB/Swiss-Prot
      A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

    2. XM_054329989.1 → XP_054185964.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

      UniProtKB/Swiss-Prot
      A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10782594..10807884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372462.1 → XP_054228437.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

    2. XM_054372463.1 → XP_054228438.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005042.4: Suppressed sequence

      Description
      NM_005042.4: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02810.3 GenPept UniProtKB/Swiss-Prot:P02810

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