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    DZANK1 double zinc ribbon and ankyrin repeat domains 1 [ Homo sapiens (human) ]

    Gene ID: 55184, updated on 2-Nov-2024

    Summary

    Official Symbol
    DZANK1provided by HGNC
    Official Full Name
    double zinc ribbon and ankyrin repeat domains 1provided by HGNC
    Primary source
    HGNC:HGNC:15858
    See related
    Ensembl:ENSG00000089091 MIM:620905; AllianceGenome:HGNC:15858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANKRD64; C20orf12; C20orf84
    Summary
    This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. [provided by RefSeq, Dec 2018]
    Expression
    Broad expression in testis (RPKM 1.9), thyroid (RPKM 1.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DZANK1 in Genome Data Viewer
    Location:
    20p11.23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18383367..18467030, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18434464..18518130, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18364011..18447674, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985418 Neighboring gene long intergenic non-protein coding RNA 851 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:18369569-18370768 Neighboring gene uncharacterized LOC124904877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12702 Neighboring gene glucosaminyl (N-acetyl) transferase 1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:18447554-18448172 Neighboring gene RNA polymerase III subunit F Neighboring gene microRNA 3192 Neighboring gene ribosomal protein L21 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10600, FLJ30892, DKFZp781J2425

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in eye photoreceptor cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within eye photoreceptor cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    double zinc ribbon and ankyrin repeat-containing protein 1
    Names
    ankyrin repeat domain 64
    ankyrin repeat-containing protein C20orf12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099407.2NP_001092877.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001092877.1

      Status: REVIEWED

      Source sequence(s)
      AK026306, AK055544, AL049646, BC130341, DQ104738
      Consensus CDS
      CCDS46582.1
      UniProtKB/Swiss-Prot
      A1L3Z8, B7ZLZ4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442, Q9NVP4
      UniProtKB/TrEMBL
      B7Z631
      Related
      ENSP00000262547.5, ENST00000262547.9
      Conserved Domains (5) summary
      cd00204
      Location:618728
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03174
      Location:1297
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:339387
      DZR; Double zinc ribbon
      pfam12796
      Location:619707
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:640672
      ANK; ANK repeat [structural motif]
    2. NM_001351683.4NP_001338612.2  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      UniProtKB/TrEMBL
      B7Z631
      Conserved Domains (4) summary
      sd00045
      Location:659691
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:358406
      DZR; Double zinc ribbon
      pfam12796
      Location:638726
      Ank_2; Ankyrin repeats (3 copies)
      pfam13287
      Location:32100
      Fn3_assoc; Fn3 associated
    3. NM_001351684.2NP_001338613.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK026306, AK299746, AL049646, AL121893
      UniProtKB/TrEMBL
      B7Z631
      Conserved Domains (4) summary
      sd00045
      Location:659691
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:358406
      DZR; Double zinc ribbon
      pfam12796
      Location:638726
      Ank_2; Ankyrin repeats (3 copies)
      pfam13287
      Location:32100
      Fn3_assoc; Fn3 associated
    4. NM_001367611.1NP_001354540.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      Consensus CDS
      CCDS93012.1
      UniProtKB/TrEMBL
      A0A8V8TNH6, B7Z2S6
      Related
      ENSP00000514418.1, ENST00000699525.1
    5. NM_001367612.1NP_001354541.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      Consensus CDS
      CCDS93013.1
      UniProtKB/TrEMBL
      A0A8V8TPU7, B7Z2S6
      Related
      ENSP00000514461.1, ENST00000699590.1
    6. NM_001367613.1NP_001354542.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      Consensus CDS
      CCDS93013.1
      UniProtKB/TrEMBL
      A0A8V8TPU7, B7Z2S6
    7. NM_001367614.1NP_001354543.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      Consensus CDS
      CCDS93014.1
      UniProtKB/TrEMBL
      A0A8V8TNE5, B7Z2S6
      Related
      ENSP00000514442.1, ENST00000699568.1
    8. NM_001367617.1NP_001354546.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      Consensus CDS
      CCDS93014.1
      UniProtKB/TrEMBL
      A0A8V8TNE5, B7Z2S6
    9. NM_001367618.1NP_001354547.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      Consensus CDS
      CCDS93014.1
      UniProtKB/TrEMBL
      A0A8V8TNE5, B7Z2S6
    10. NM_001367619.1NP_001354548.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      UniProtKB/TrEMBL
      A0A0A0MRE2
    11. NM_018152.3NP_060622.2  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      UniProtKB/TrEMBL
      A0A0A0MRE2
      Related
      ENSP00000514474.1, ENST00000699607.1
      Conserved Domains (4) summary
      cd00204
      Location:451561
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12773
      Location:166214
      DZR; Double zinc ribbon
      pfam12796
      Location:452540
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:473505
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_160273.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893
      Related
      ENST00000699593.1
    2. NR_160274.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049646, AL121893

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      18383367..18467030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027915.3XP_016883404.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TNH6, B7Z2S6
      Conserved Domains (5) summary
      cd00204
      Location:624734
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03174
      Location:1297
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:339387
      DZR; Double zinc ribbon
      pfam12796
      Location:625713
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:646678
      ANK; ANK repeat [structural motif]
    2. XM_017027911.2XP_016883400.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TNE5, B7Z2S6
      Conserved Domains (5) summary
      cd00204
      Location:643753
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03174
      Location:1297
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:358406
      DZR; Double zinc ribbon
      pfam12796
      Location:644732
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:665697
      ANK; ANK repeat [structural motif]
    3. XM_006723584.3XP_006723647.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      B7Z2S6
      Conserved Domains (5) summary
      cd00204
      Location:562672
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03174
      Location:1297
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:277325
      DZR; Double zinc ribbon
      pfam12796
      Location:563651
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:584616
      ANK; ANK repeat [structural motif]
    4. XM_047440251.1XP_047296207.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X9

      UniProtKB/Swiss-Prot
      A1L3Z8, B7ZLZ4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442, Q9NVP4
      Related
      ENSP00000351734.6, ENST00000358866.10
    5. XM_047440248.1XP_047296204.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X4

    6. XM_017027910.2XP_016883399.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TNE5, B7Z2S6
      Conserved Domains (5) summary
      cd00204
      Location:643753
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03174
      Location:1297
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:358406
      DZR; Double zinc ribbon
      pfam12796
      Location:644732
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:665697
      ANK; ANK repeat [structural motif]
    7. XM_011529272.3XP_011527574.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011527574.1

      UniProtKB/TrEMBL
      A0A8V8TNE5, B7Z2S6
      Conserved Domains (5) summary
      cd00204
      Location:643753
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03174
      Location:1297
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:358406
      DZR; Double zinc ribbon
      pfam12796
      Location:644732
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:665697
      ANK; ANK repeat [structural motif]
    8. XM_047440250.1XP_047296206.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X7

    9. XM_047440249.1XP_047296205.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X6

    10. XM_011529268.3XP_011527570.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      B7Z2S6
      Conserved Domains (5) summary
      cd00204
      Location:652762
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03174
      Location:21106
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:367415
      DZR; Double zinc ribbon
      pfam12796
      Location:653741
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:674706
      ANK; ANK repeat [structural motif]
    11. XM_017027916.3XP_016883405.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      B7Z2S6
    12. XM_017027913.3XP_016883402.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      B7Z2S6
    13. XM_017027912.3XP_016883401.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B7Z2S6
    14. XM_047440252.1XP_047296208.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X13

      Related
      ENSP00000349774.5, ENST00000357236.8
    15. XM_024451934.2XP_024307702.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A0A0MRE2
      Conserved Domains (3) summary
      cd00204
      Location:515625
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:537569
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:230278
      DZR; Double zinc ribbon
    16. XM_017027921.3XP_016883410.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0A0MRE2
      Related
      ENSP00000328866.6, ENST00000329494.9
    17. XM_011529277.3XP_011527579.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      C9J2A8
      Conserved Domains (4) summary
      cd00204
      Location:305415
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12773
      Location:2068
      DZR; Double zinc ribbon
      pfam12796
      Location:306394
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:327359
      ANK; ANK repeat [structural motif]
    18. XM_047440253.1XP_047296209.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X16

    RNA

    1. XR_007067462.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      18434464..18518130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323597.1XP_054179572.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TNH6
    2. XM_054323588.1XP_054179563.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TNE5
    3. XM_054323602.1XP_054179577.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X11

    4. XM_054323600.1XP_054179575.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X9

      UniProtKB/Swiss-Prot
      A1L3Z8, B7ZLZ4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442, Q9NVP4
    5. XM_054323594.1XP_054179569.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X4

    6. XM_054323590.1XP_054179565.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TNE5
    7. XM_054323599.1XP_054179574.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X9

      UniProtKB/Swiss-Prot
      A1L3Z8, B7ZLZ4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442, Q9NVP4
    8. XM_054323598.1XP_054179573.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TNH6
    9. XM_054323589.1XP_054179564.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TNE5
    10. XM_054323591.1XP_054179566.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TNE5
    11. XM_054323596.1XP_054179571.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X7

    12. XM_054323595.1XP_054179570.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X6

    13. XM_054323593.1XP_054179568.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X18

    14. XM_054323587.1XP_054179562.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X1

    15. XM_054323601.1XP_054179576.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X10

    16. XM_054323592.1XP_054179567.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X3

    17. XM_054323586.1XP_054179561.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X17

    18. XM_054323604.1XP_054179579.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X13

    19. XM_054323603.1XP_054179578.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X12

    20. XM_054323605.1XP_054179580.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X14

    21. XM_054323606.1XP_054179581.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X15

    22. XM_054323607.1XP_054179582.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X16

    RNA

    1. XR_008485267.1 RNA Sequence