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    Fcmr Fc mu receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 548326, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fcmrprovided by RGD
    Official Full Name
    Fc mu receptorprovided by RGD
    Primary source
    RGD:1359282
    See related
    EnsemblRapid:ENSRNOG00000004441 AllianceGenome:RGD:1359282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Toso; Faim3; FAIM3g; IgM FcR
    Summary
    Predicted to enable IgM binding activity; high-affinity IgM receptor activity; and polymeric immunoglobulin binding activity. Predicted to be involved in several processes, including Fc receptor-mediated immune complex endocytosis; humoral immune response mediated by circulating immunoglobulin; and regulation of B cell receptor signaling pathway. Predicted to act upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; and negative regulation of lymphocyte apoptotic process. Predicted to be located in bounding membrane of organelle; external side of plasma membrane; and trans-Golgi network membrane. Predicted to be active in plasma membrane. Orthologous to human FCMR (Fc mu receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 267.7), Thymus (RPKM 47.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fcmr in Genome Data Viewer
    Location:
    13q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (44889628..44903926)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42337363..42351706)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47602701..47617065)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Fc alpha and mu receptor Neighboring gene polymeric immunoglobulin receptor Neighboring gene interleukin 24 Neighboring gene interleukin 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. Song Y, et al. J Biol Chem, 2005 Mar 11. PMID 15632112
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables IgM binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables IgM binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables high-affinity IgM receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables high-affinity IgM receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables polymeric immunoglobulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polymeric immunoglobulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Fc receptor-mediated immune complex endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Fc receptor-mediated immune complex endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in humoral immune response mediated by circulating immunoglobulin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immunoglobulin transcytosis in epithelial cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immunoglobulin transcytosis in epithelial cells ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within inhibition of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of lymphocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin mu Fc receptor
    Names
    Fas apoptotic inhibitory molecule 3
    Fc fragment of IgM receptor
    IgM Fc fragment receptor
    regulator of Fas-induced apoptosis Toso

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014843.2 → NP_001014843.1  immunoglobulin mu Fc receptor precursor

      See identical proteins and their annotated locations for NP_001014843.1

      Status: VALIDATED

      Source sequence(s)
      BC088197, JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5M871
      UniProtKB/TrEMBL
      A0A8I5ZSV7
      Related
      ENSRNOP00000036615.5, ENSRNOT00000038822.7
      Conserved Domains (2) summary
      cd05716
      Location:27 → 120
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25 → 121
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      44889628..44903926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249715.5 → XP_006249777.1  immunoglobulin mu Fc receptor isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHV3, A6IC06
      Conserved Domains (2) summary
      cd05716
      Location:48 → 141
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:46 → 142
      IG_like; Immunoglobulin like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M871.1 GenPept UniProtKB/Swiss-Prot:Q5M871

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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