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    TAF7L TATA-box binding protein associated factor 7 like [ Homo sapiens (human) ]

    Gene ID: 54457, updated on 28-Oct-2024

    Summary

    Official Symbol
    TAF7Lprovided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 7 likeprovided by HGNC
    Primary source
    HGNC:HGNC:11548
    See related
    Ensembl:ENSG00000102387 MIM:300314; AllianceGenome:HGNC:11548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT40; TAF2Q
    Summary
    This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
    Expression
    Restricted expression toward testis (RPKM 16.4) See more
    Orthologs
    NEW
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    Genomic context

    See TAF7L in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101268257..101293083, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99712369..99751819, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100523245..100548071, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene YWHAQ pseudogene 8 Neighboring gene dystrophin related protein 2 Neighboring gene RNA, U6 small nuclear 934, pseudogene Neighboring gene NANOGNB pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23157

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 7-like
    Names
    RNA polymerase II TBP-associated factor subunit Q
    TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
    TATA box-binding protein-associated factor 50 kDa
    TBP-associated factor, RNA polymerase II, Q
    cancer/testis antigen 40
    transcription initiation factor TFIID 50 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016220.2 RefSeqGene

      Range
      6749..29826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168474.2NP_001161946.1  transcription initiation factor TFIID subunit 7-like isoform 2

      See identical proteins and their annotated locations for NP_001161946.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AF285595, BC043391
      Consensus CDS
      CCDS55466.1
      UniProtKB/Swiss-Prot
      Q5H9L4
      Related
      ENSP00000349235.1, ENST00000356784.2
      Conserved Domains (1) summary
      pfam04658
      Location:12190
      TAFII55_N; TAFII55 protein conserved region
    2. NM_001410720.1NP_001397649.1  transcription initiation factor TFIID subunit 7-like isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL109801, Z68331
      Consensus CDS
      CCDS94640.1
      Related
      ENSP00000320283.6, ENST00000324762.10
    3. NM_024885.4NP_079161.3  transcription initiation factor TFIID subunit 7-like isoform 1

      See identical proteins and their annotated locations for NP_079161.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL109801, BC043391, DB455298
      Consensus CDS
      CCDS35347.1
      UniProtKB/Swiss-Prot
      Q5H9L4, Q5H9L6, Q86XI4, Q9BXU5, Q9H5R0
      Related
      ENSP00000361998.3, ENST00000372907.7
      Conserved Domains (1) summary
      pfam04658
      Location:98276
      TAFII55_N; TAFII55 protein conserved region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      101268257..101293083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724664.2XP_006724727.1  transcription initiation factor TFIID subunit 7-like isoform X1

      Conserved Domains (1) summary
      pfam04658
      Location:98276
      TAFII55_N; TAFII55 protein conserved region
    2. XM_005262152.2XP_005262209.1  transcription initiation factor TFIID subunit 7-like isoform X2

      See identical proteins and their annotated locations for XP_005262209.1

      Conserved Domains (1) summary
      pfam04658
      Location:12190
      TAFII55_N; TAFII55 protein conserved region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      99712369..99751819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327264.1XP_054183239.1  transcription initiation factor TFIID subunit 7-like isoform X4

    2. XM_054327263.1XP_054183238.1  transcription initiation factor TFIID subunit 7-like isoform X3

    3. XM_054327265.1XP_054183240.1  transcription initiation factor TFIID subunit 7-like isoform X2