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    PCBP3 poly(rC) binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 54039, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PCBP3provided by HGNC
    Official Full Name
    poly(rC) binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:8651
    See related
    Ensembl:ENSG00000183570 MIM:608502; AllianceGenome:HGNC:8651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCBP3OT; ALPHA-CP3; PCBP3-OT1
    Summary
    This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
    Expression
    Broad expression in testis (RPKM 8.3), endometrium (RPKM 4.4) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PCBP3 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (45643725..45942450)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (44013409..44318564)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47063639..47362364)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene collagen type XVIII alpha 1 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46934825-46935332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46935840-46936346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18591 Neighboring gene Sharpr-MPRA regulatory region 1559 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46948644-46948814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46954106-46954980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13403 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46962482-46962994 Neighboring gene solute carrier family 19 member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46970045-46970201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46975660-46976554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46980259-46980968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46998853-46999354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47001008-47001944 Neighboring gene uncharacterized LOC107985485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47009554-47010054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47015623-47016124 Neighboring gene Sharpr-MPRA regulatory region 7423 Neighboring gene MPRA-validated peak4424 silencer Neighboring gene MPRA-validated peak4426 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47031725-47032226 Neighboring gene long intergenic non-protein coding RNA 1694 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:47053121-47054320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47057095-47057612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13411 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:47204393-47205264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47236921-47237422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47237423-47237922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47241669-47242354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47244540-47245132 Neighboring gene MPRA-validated peak4427 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47255439-47255946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47257017-47257560 Neighboring gene PCBP3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47274544-47275220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47275221-47275896 Neighboring gene uncharacterized LOC124905044 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:47278335-47279534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47300489-47301293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47308837-47309710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47309711-47310583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47312061-47312782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47317748-47318248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47318249-47318749 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:47336390-47336616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47339089-47339588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47371642-47372327 Neighboring gene Sharpr-MPRA regulatory region 9072 Neighboring gene uncharacterized LOC101928796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47393951-47394751 Neighboring gene uncharacterized LOC105372841 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:47401442-47402304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Targeting a KH-domain protein with RNA decoys. Makeyev AV, et al. RNA, 2002 Sep. PMID 12358435, Free PMC Article
    2. Proteomic Identification of FLT3 and PCBP3 as Potential Prognostic Biomarkers for Pancreatic Cancer. Ger M, et al. Anticancer Res, 2018 Oct. PMID 30275197
    3. The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. Makeyev AV, et al. RNA, 2002 Mar. PMID 12003487, Free PMC Article
    4. LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3. Qiu X, et al. Mol Cancer Res, 2022 Nov 3. PMID 35920801
    5. Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations. Wang Y, et al. Gene, 2010 Feb 1. PMID 19914360, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3.
      Title: LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3.
    2. Low PCBP3 expression is associated with Pancreatic ductal adenocarcinoma.
      Title: Proteomic Identification of FLT3 and PCBP3 as Potential Prognostic Biomarkers for Pancreatic Cancer.
    3. Study examined splicing factors located on chromosome 21 for their effect on tau exon 10 and discovered that one of them, hnRNPE3 (PCBP3), modestly activates splicing of exon 10 by interacting with its proximal downstream intron around position +19.
      Title: Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of poly(rC) binding protein 3 (PCBP3) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ44028

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-rich single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA metabolic process NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(rC)-binding protein 3
    Names
    PCBP3 overlapping transcript 1
    PCBP3-overlapping transcript
    poly(rC) binding protein 3 overlapping transcript

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130141.2 → NP_001123613.1  poly(rC)-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001123613.1

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL592528
      Consensus CDS
      CCDS46652.1
      UniProtKB/TrEMBL
      J3QT27
      Related
      ENSP00000383163.1, ENST00000400308.5
      Conserved Domains (2) summary
      cd00105
      Location:269 → 331
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:131 → 195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    2. NM_001348238.2 → NP_001335167.1  poly(rC)-binding protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 15, encodes isoform 3.
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS86994.1
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (1) summary
      cl00098
      Location:285 → 359
      KH-I; K homology (KH) RNA-binding domain, type I

    3. NM_001348239.2 → NP_001335168.1  poly(rC)-binding protein 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      UniProtKB/TrEMBL
      Q5MJP6
      Conserved Domains (2) summary
      cd02396
      Location:131 → 195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:317 → 381
      KH_1; KH domain

    4. NM_001348240.2 → NP_001335169.1  poly(rC)-binding protein 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 16, encodes the longest isoform (5).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      UniProtKB/TrEMBL
      Q5MJP6
      Conserved Domains (1) summary
      cl00098
      Location:309 → 383
      KH-I; K homology (KH) RNA-binding domain, type I

    5. NM_001348241.2 → NP_001335170.1  poly(rC)-binding protein 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (2) summary
      cd02396
      Location:131 → 195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:306 → 370
      KH_1; KH domain

    6. NM_001348242.2 → NP_001335171.1  poly(rC)-binding protein 3 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 13, encodes isoform 7.
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      UniProtKB/TrEMBL
      Q5MJP6
      Conserved Domains (3) summary
      cd22519
      Location:93 → 171
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:254 → 328
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cl00098
      Location:6 → 82
      KH-I; K homology (KH) RNA-binding domain, type I

    7. NM_001348243.2 → NP_001335172.1  poly(rC)-binding protein 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL592528
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (2) summary
      cd02396
      Location:131 → 195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:274 → 338
      KH_1; KH domain

    8. NM_001348244.2 → NP_001335173.1  poly(rC)-binding protein 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AK094301, AL592528
      Consensus CDS
      CCDS86993.1
      UniProtKB/TrEMBL
      J3QT27
      Related
      ENSP00000383165.1, ENST00000400310.5
      Conserved Domains (2) summary
      cd02396
      Location:131 → 195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:275 → 339
      KH_1; KH domain

    9. NM_001348245.2 → NP_001335174.1  poly(rC)-binding protein 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL592528
      UniProtKB/TrEMBL
      Q5MJP6
      Conserved Domains (2) summary
      cd02396
      Location:131 → 195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:297 → 361
      KH_1; KH domain

    10. NM_001382276.1 → NP_001369205.1  poly(rC)-binding protein 3 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 7, encodes isoform 7.
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      UniProtKB/TrEMBL
      Q5MJP6
      Conserved Domains (3) summary
      cd22519
      Location:93 → 171
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:254 → 328
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cl00098
      Location:6 → 82
      KH-I; K homology (KH) RNA-binding domain, type I

    11. NM_001382277.1 → NP_001369206.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    12. NM_001382278.1 → NP_001369207.1  poly(rC)-binding protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AJ011931, AJ239328, AL592528
      Consensus CDS
      CCDS86994.1
      UniProtKB/TrEMBL
      J3QT27
      Related
      ENSP00000383164.1, ENST00000400309.5
      Conserved Domains (1) summary
      cl00098
      Location:285 → 359
      KH-I; K homology (KH) RNA-binding domain, type I

    13. NM_001382279.1 → NP_001369208.1  poly(rC)-binding protein 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 5, encodes the longest isoform (5).
      Source sequence(s)
      AJ011931, AJ239328, AL592528
      UniProtKB/TrEMBL
      Q5MJP6
      Related
      ENSP00000401198.2, ENST00000449640.5
      Conserved Domains (1) summary
      cl00098
      Location:309 → 383
      KH-I; K homology (KH) RNA-binding domain, type I

    14. NM_001382281.1 → NP_001369210.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    15. NM_001382282.1 → NP_001369211.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    16. NM_001382283.1 → NP_001369212.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    17. NM_001382284.1 → NP_001369213.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    18. NM_001382285.1 → NP_001369214.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    19. NM_001382286.1 → NP_001369215.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    20. NM_001382287.1 → NP_001369216.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Related
      ENSP00000383168.1, ENST00000400314.5
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    21. NM_001382288.1 → NP_001369217.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    22. NM_001384156.1 → NP_001371085.1  poly(rC)-binding protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 14, and 17-25 all encode the same isoform (1).
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Related
      ENSP00000505796.1, ENST00000681687.1
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    23. NM_020528.3 → NP_065389.2  poly(rC)-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_065389.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 14 and 17-25, encodes isoform 1.
      Source sequence(s)
      AJ011931, AJ239328, AL592528
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      A8MPS2, A8MQ26, B7WNN9, B7WPC1, P57721, Q8N9K6, Q96EP6
      UniProtKB/TrEMBL
      J3QT27
      Conserved Domains (3) summary
      cd22516
      Location:38 → 114
      KH-I_PCBP3_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22519
      Location:125 → 203
      KH-I_PCBP3_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
      cd22522
      Location:286 → 360
      KH-I_PCBP3_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins

    RNA

    1. NR_145492.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528

    2. NR_145493.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL592528

    3. NR_189734.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CP068257

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      45643725..45942450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      44013409..44318564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57721.2 GenPept UniProtKB/Swiss-Prot:P57721

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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