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    TBXA2R thromboxane A2 receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 538783, updated on 4-Oct-2024

    Summary

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    Official Symbol
    TBXA2Rprovided by VGNC
    Official Full Name
    thromboxane A2 receptorprovided by VGNC
    Primary source
    VGNC:VGNC:35673
    See related
    BGD:BT16577; Ensembl:ENSBTAG00000014944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TBXA2R in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (20330001..20343533)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene cactin, spliceosome C complex subunit Neighboring gene uncharacterized LOC100849681 Neighboring gene GIPC PDZ domain containing family member 3 Neighboring gene high mobility group 20B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, tissue-specific expression and regulation of the bovine thromboxane A2 receptor. Muck S, et al. Adv Exp Med Biol, 1997. PMID 9561101
    2. The bovine thromboxane A2 receptor: molecular cloning, expression, and functional characterization. Muck S, et al. Naunyn Schmiedebergs Arch Pharmacol, 1998 Jan. PMID 9459567
    3. Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Zhang M, et al. Arterioscler Thromb Vasc Biol, 2011 Jan. PMID 20947827, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables thromboxane A2 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thromboxane A2 receptor
    Names
    TXA2-R
    prostanoid TP receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167919.1 → NP_001161391.1  thromboxane A2 receptor

      See identical proteins and their annotated locations for NP_001161391.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000007
      UniProtKB/Swiss-Prot
      Q95124, Q95125
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 308
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20330001..20343533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024994470.2 → XP_024850238.1  thromboxane A2 receptor isoform X1

      UniProtKB/TrEMBL
      A0AAA9S8X2
      Related
      ENSBTAP00000081734.1, ENSBTAT00000096872.1
      Conserved Domains (3) summary
      cd15143
      Location:27 → 51
      7tmA_TXA2_R; TM helix 1 [structural motif]
      cl26464
      Location:265 → 354
      Atrophin-1; Atrophin-1 family
      cl28897
      Location:25 → 262
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_005208963.5 → XP_005209020.1  thromboxane A2 receptor isoform X2

      See identical proteins and their annotated locations for XP_005209020.1

      UniProtKB/Swiss-Prot
      Q95124, Q95125
      Related
      ENSBTAP00000019892.3, ENSBTAT00000019892.5
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 308
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. XM_059888325.1 → XP_059744308.1  thromboxane A2 receptor isoform X3

    4. XM_059888326.1 → XP_059744309.1  thromboxane A2 receptor isoform X4

    5. XM_059888324.1 → XP_059744307.1  thromboxane A2 receptor isoform X1

      UniProtKB/TrEMBL
      A0AAA9S8X2

    RNA

    1. XR_003035388.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95125.2 GenPept UniProtKB/Swiss-Prot:Q95125

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.