P2RY13 purinergic receptor P2Y13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: P2RY13provided by HGNC
Official Full Name: purinergic receptor P2Y13provided by HGNC
Primary source: HGNC:HGNC:4537
See related: Ensembl:ENSG00000181631 MIM:606380; AllianceGenome:HGNC:4537
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPCR1; GPR86; GPR94; P2Y13; SP174; FKSG77
Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]
Expression: Broad expression in spleen (RPKM 21.1), appendix (RPKM 14.3) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q25.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (151326312..151329549, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (154077312..154080550, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (151044100..151047337, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2Y13 receptor deficiency favors adipose tissue lipolysis and worsens insulin resistance and fatty liver disease.
Title: P2Y13 receptor deficiency favors adipose tissue lipolysis and worsens insulin resistance and fatty liver disease.
Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y13 receptor and nitric oxide signaling.
Title: Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y(13) receptor and nitric oxide signaling.
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway.
Title: P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway.
Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.
Title: Targeting the P2Y(13) Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.
Evaluation of tumor microenvironmental immune regulation and prognostic in lung adenocarcinoma from the perspective of purinergic receptor P2Y13.
Title: Evaluation of tumor microenvironmental immune regulation and prognostic in lung adenocarcinoma from the perspective of purinergic receptor P2Y13.
P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells.
Title: P2Y(13) and P2X(7) receptors modulate mechanically induced adenosine triphosphate release from mast cells.
Nucleotides-Induced Changes in the Mechanical Properties of Living Endothelial Cells and Astrocytes, Analyzed by Atomic Force Microscopy.
Title: Nucleotides-Induced Changes in the Mechanical Properties of Living Endothelial Cells and Astrocytes, Analyzed by Atomic Force Microscopy.
Common p2y13 polymorphisms are associated with plasma inhibitory factor 1 and lipoprotein(a) concentrations, heart rate and body fat mass and may modulate cardiovascular risk.
Title: Common p2y(13) polymorphisms are associated with plasma inhibitory factor 1 and lipoprotein(a) concentrations, heart rate and body fat mass: The GENES study.
The pattern of responsiveness to more selective P2-antagonists implies that both P2Y13 and P2X7 receptors are involved in Epsilon-toxin-of Clostridium perfringens induced hemolysis in human species.
Title: Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors.
results demonstrate a crosstalk between two metabotropic and one ionotropic purinergic receptor that regulates cAMP levels through adenylate cyclase 5 and modulates axonal elongation triggered by neurotropic factors and the PI3K-Akt-GSK3 pathway
Title: Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91840 (e-PCR)
- UniSTS:90409

D3S4238 (e-PCR)
- UniSTS:71246

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled purinergic nucleotide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: P2Y purinoceptor 13

Names: G protein-coupled receptor 86; G-protein coupled receptor 94; purinergic receptor P2Y, G-protein coupled, 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176894.3 → NP_795713.2 P2Y purinoceptor 13

See identical proteins and their annotated locations for NP_795713.2

Status: REVIEWED

Source sequence(s)

AC024886, DA676457

Consensus CDS

CCDS3158.2

UniProtKB/Swiss-Prot

B2R827, Q05C50, Q6DKN4, Q8IUT5, Q8TDU7, Q9BPV8, Q9BY61

UniProtKB/TrEMBL

G4XH60

Related

ENSP00000320376.5, ENST00000325602.6

Conserved Domains (1) summary

pfam00001
Location:62 → 317

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

151326312..151329549 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006713664.1 → XP_006713727.1 P2Y purinoceptor 13 isoform X1

Conserved Domains (1) summary

PHA03087
Location:50 → 164

PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

154077312..154080550 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054346899.1 → XP_054202874.1 P2Y purinoceptor 13 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_023914.2: Suppressed sequence

Description

NM_023914.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to include intronic sequence.