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    ITGB8 integrin subunit beta 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 536286, updated on 10-Oct-2024

    Summary

    Official Symbol
    ITGB8provided by VGNC
    Official Full Name
    integrin subunit beta 8provided by VGNC
    Primary source
    VGNC:VGNC:30333
    See related
    BGD:BT10180; Ensembl:ENSBTAG00000003709
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
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    Genomic context

    See ITGB8 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (29021938..29120852)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene MET transcriptional regulator MACC1 Neighboring gene large ribosomal subunit protein eL6-like Neighboring gene uncharacterized LOC132345074 Neighboring gene uncharacterized LOC132345073 Neighboring gene ATP binding cassette subfamily B member 5 Neighboring gene Sp8 transcription factor

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin beta-8
    Names
    integrin, beta 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192875.3NP_001179804.1  integrin beta-8 precursor

      See identical proteins and their annotated locations for NP_001179804.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000004
      UniProtKB/TrEMBL
      A0AAA9SZ14, F1MVW3
      Related
      ENSBTAP00000004833.4, ENSBTAT00000004833.6
      Conserved Domains (1) summary
      smart00187
      Location:54468
      INB; Integrin beta subunits (N-terminal portion of extracellular region)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29021938..29120852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885664.1XP_059741647.1  integrin beta-8 isoform X3

    2. XM_059885663.1XP_059741646.1  integrin beta-8 isoform X1

    3. XM_015468532.3XP_015324018.1  integrin beta-8 isoform X2

      Conserved Domains (1) summary
      cl00057
      Location:1334
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...