U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    BRAF B-Raf proto-oncogene, serine/threonine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 536051, updated on 10-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    BRAFprovided by VGNC
    Official Full Name
    B-Raf proto-oncogene, serine/threonine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:26551
    See related
    BGD:BT25565; Ensembl:ENSBTAG00000021761
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BRAF in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (104016173..104194462, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104972256 Neighboring gene uncharacterized LOC132345136 Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene 5S ribosomal RNA Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene uncharacterized LOC101907501 Neighboring gene mitochondrial ribosomal protein S33

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase B-raf
    XP_005205968.1
    XP_005205973.1
    XP_005205974.1
    XP_005205975.1
    XP_024846954.1
    XP_024846956.1
    XP_024846957.1
    XP_059741940.1
    XP_059741941.1
    XP_059741942.1
    XP_059741943.1
    XP_059741944.1
    XP_059741945.1
    XP_059741946.1
    XP_059741947.1
    XP_059741948.1
    XP_059741949.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      104016173..104194462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885960.1 → XP_059741943.1  serine/threonine-protein kinase B-raf isoform X4

    2. XM_059885958.1 → XP_059741941.1  serine/threonine-protein kinase B-raf isoform X2

      Related
      ENSBTAP00000090920.1, ENSBTAT00000129444.1

    3. XM_059885957.1 → XP_059741940.1  serine/threonine-protein kinase B-raf isoform X1

    4. XM_059885959.1 → XP_059741942.1  serine/threonine-protein kinase B-raf isoform X3

    5. XM_059885961.1 → XP_059741944.1  serine/threonine-protein kinase B-raf isoform X5

    6. XM_005205911.5 → XP_005205968.1  serine/threonine-protein kinase B-raf isoform X9

      See identical proteins and their annotated locations for XP_005205968.1

      UniProtKB/TrEMBL
      A0AAA9T2F0
      Related
      ENSBTAP00000086663.1, ENSBTAT00000124680.1
      Conserved Domains (4) summary
      cd01816
      Location:155 → 226
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:462 → 714
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00069
      Location:457 → 712
      Pkinase; Protein kinase domain
      pfam00130
      Location:234 → 279
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    7. XM_024991189.2 → XP_024846957.1  serine/threonine-protein kinase B-raf isoform X8

      UniProtKB/TrEMBL
      A0AAA9T2F0
      Related
      ENSBTAP00000088001.1, ENSBTAT00000126916.1
      Conserved Domains (3) summary
      cd01816
      Location:155 → 226
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:462 → 709
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:234 → 279
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    8. XM_024991188.2 → XP_024846956.1  serine/threonine-protein kinase B-raf isoform X7

      UniProtKB/TrEMBL
      A0AAA9T2F0, A0AAA9T3I8
      Related
      ENSBTAP00000091205.1, ENSBTAT00000113360.1
      Conserved Domains (3) summary
      cd01816
      Location:155 → 226
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:462 → 709
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:234 → 279
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    9. XM_059885966.1 → XP_059741949.1  serine/threonine-protein kinase B-raf isoform X16

      UniProtKB/TrEMBL
      A0AAA9SS15
      Related
      ENSBTAP00000086889.1, ENSBTAT00000116466.1

    10. XM_024991186.2 → XP_024846954.1  serine/threonine-protein kinase B-raf isoform X6

      UniProtKB/TrEMBL
      A0AAA9T2F0
      Conserved Domains (3) summary
      cd01816
      Location:155 → 226
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:462 → 709
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:234 → 279
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    11. XM_059885965.1 → XP_059741948.1  serine/threonine-protein kinase B-raf isoform X13

      Related
      ENSBTAP00000029006.7, ENSBTAT00000029006.7

    12. XM_059885963.1 → XP_059741946.1  serine/threonine-protein kinase B-raf isoform X11

    13. XM_059885962.1 → XP_059741945.1  serine/threonine-protein kinase B-raf isoform X10

    14. XM_059885964.1 → XP_059741947.1  serine/threonine-protein kinase B-raf isoform X12

      Related
      ENSBTAP00000057958.2, ENSBTAT00000068933.2

    15. XM_005205916.5 → XP_005205973.1  serine/threonine-protein kinase B-raf isoform X14

      See identical proteins and their annotated locations for XP_005205973.1

      UniProtKB/TrEMBL
      A0A3Q1M353
      Conserved Domains (4) summary
      cd01816
      Location:155 → 226
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:462 → 665
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:234 → 279
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam07714
      Location:456 → 662
      Pkinase_Tyr; Protein tyrosine kinase

    16. XM_005205918.3 → XP_005205975.1  serine/threonine-protein kinase B-raf isoform X15

      UniProtKB/TrEMBL
      A0A3Q1M353
      Conserved Domains (4) summary
      cd01816
      Location:155 → 226
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:462 → 663
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:234 → 279
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam07714
      Location:456 → 662
      Pkinase_Tyr; Protein tyrosine kinase

    17. XM_005205917.5 → XP_005205974.1  serine/threonine-protein kinase B-raf isoform X14

      See identical proteins and their annotated locations for XP_005205974.1

      UniProtKB/TrEMBL
      A0A3Q1M353
      Related
      ENSBTAP00000064502.2, ENSBTAT00000086962.2
      Conserved Domains (4) summary
      cd01816
      Location:155 → 226
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:462 → 665
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:234 → 279
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam07714
      Location:456 → 662
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.