TMLHE trimethyllysine hydroxylase, epsilon [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TMLHEprovided by VGNC
Official Full Name: trimethyllysine hydroxylase, epsilonprovided by VGNC
Primary source: VGNC:VGNC:36134
See related: BGD:BT15783; Ensembl:ENSBTAG00000011648
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (35551796..35602891)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables trimethyllysine dioxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in carnitine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: trimethyllysine dioxygenase, mitochondrial

Names: TML dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TMLD; epsilon-trimethyllysine 2-oxoglutarate dioxygenase

NP_001069532.1

EC 1.14.11.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076064.1 → NP_001069532.1 trimethyllysine dioxygenase, mitochondrial

See identical proteins and their annotated locations for NP_001069532.1

Status: PROVISIONAL

Source sequence(s)

BC120318

UniProtKB/Swiss-Prot

Q0VC74

UniProtKB/TrEMBL

A0AAA9SLG6

Related

ENSBTAP00000015469.5, ENSBTAT00000015469.5

Conserved Domains (3) summary

cd00250
Location:142 → 408

CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...

TIGR02410
Location:70 → 419

carnitine_TMLD; trimethyllysine dioxygenase

cl01414
Location:54 → 133

DUF971; Protein of unknown function (DUF971)