HSPB6 heat shock protein family B (small) member 6 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: HSPB6
Gene description: heat shock protein family B (small) member 6
See related: BGD:BT20036; Ensembl:ENSBTAG00000018598
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: HSP20
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (46466909..46469460, complement)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP20 is associated with both actin and alpha-actinin; activation of cyclic nucleotide-dependent signaling pathways leads to increases in the phosphorylation of HSP20 and a decrease in the association of HSP20 with alpha-actinin.
Title: The small heat shock protein (HSP) 20 is dynamically associated with the actin cross-linking protein actinin.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein refolding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to heat	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heat shock protein beta-6

Names: heat shock protein, alpha-crystallin-related, B6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076027.1 → NP_001069495.1 heat shock protein beta-6

See identical proteins and their annotated locations for NP_001069495.1

Status: PROVISIONAL

Source sequence(s)

BC118368

UniProtKB/Swiss-Prot

A1A4M7, Q148F8

UniProtKB/TrEMBL

A0A1B3B5V9

Conserved Domains (2) summary

pfam00525
Location:5 → 56

Crystallin; Alpha crystallin A chain, N terminal

cl00175
Location:66 → 144

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

Range

46466909..46469460 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005218978.5 → XP_005219035.2 heat shock protein beta-6 isoform X1

UniProtKB/TrEMBL

A0A1B3B5V9

Related

ENSBTAP00000024749.7, ENSBTAT00000024749.7

Conserved Domains (2) summary

pfam00525
Location:5 → 56

Crystallin; Alpha crystallin A chain, N terminal

cl00175
Location:66 → 155

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.