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    S100A9 S100 calcium binding protein A9 [ Bos taurus (domestic cattle) ]

    Gene ID: 532569, updated on 4-Oct-2024

    Summary

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    Official Symbol
    S100A9provided by VGNC
    Official Full Name
    S100 calcium binding protein A9provided by VGNC
    Primary source
    VGNC:VGNC:34247
    See related
    Ensembl:ENSBTAG00000006505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See S100A9 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (17115128..17117829, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A8 Neighboring gene S100 calcium binding protein A12 Neighboring gene uncharacterized LOC132344836 Neighboring gene peptidoglycan recognition protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro. Funeshima N, et al. PLoS One, 2020. PMID 31945120, Free PMC Article
    2. Influence of energy balance on the antimicrobial peptides S100A8 and S100A9 in the endometrium of the post-partum dairy cow. Swangchan-Uthai T, et al. Reproduction, 2013 May. PMID 23533291, Free PMC Article
    3. Nuclear proteins of the bovine esophageal epithelium. I. Monoclonal antibody W2 specifically reacts with condensed nuclei of differentiated superficial cells. Tang TK, et al. J Cell Sci, 1993 Feb. PMID 8505358
    4. The 23-kilodalton protein, a substrate of protein kinase C, in bovine neutrophil cytosol is a member of the S100 family. Dianoux AC, et al. Biochemistry, 1992 Jun 30. PMID 1610833
    5. Nonsynonymous DNA variation in the functional domain of the S100A7, -A8, -A9 genes in taurine cattle and yak. Luo Z, et al. Anim Genet, 2018 Aug. PMID 29774569

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that direct exposure to S100A9 exerted adverse effects on sperm function and embryo development. These findings suggest that excessive dose of S100A9 may have an adverse effect to the reproductive machinery by inducing inflammation and tissue dysfunction.
      Title: Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro.
    2. study of nonsynonymous DNA variation in the functional domain of the S100A7, -A8, -A9 genes in taurine cattle and yak
      Title: Nonsynonymous DNA variation in the functional domain of the S100A7, -A8, -A9 genes in taurine cattle and yak.
    3. Data suggest that up-regulation of S100A8 and S100A9 is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
      Title: Influence of energy balance on the antimicrobial peptides S100A8 and S100A9 in the endometrium of the post-partum dairy cow.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC137042

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in astrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in autocrine signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chronic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in leukocyte migration involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-cysteine S-nitrosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of integrin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein S100-A9
    Names
    BEE22
    calgranulin-B
    neutrophil cytosolic 23 kDa protein
    p23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046328.2 → NP_001039793.1  protein S100-A9

      See identical proteins and their annotated locations for NP_001039793.1

      Status: PROVISIONAL

      Source sequence(s)
      BC111626
      UniProtKB/Swiss-Prot
      P28783
      Conserved Domains (1) summary
      cd05030
      Location:6 → 94
      calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17115128..17117829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005203730.5 → XP_005203787.2  protein S100-A9 isoform X1

      UniProtKB/TrEMBL
      F1MHS5
      Conserved Domains (1) summary
      cd05030
      Location:6 → 94
      calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

    2. XM_005203729.5 → XP_005203786.2  protein S100-A9 isoform X1

      UniProtKB/TrEMBL
      F1MHS5
      Conserved Domains (1) summary
      cd05030
      Location:6 → 94
      calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

    3. XM_005203728.3 → XP_005203785.2  protein S100-A9 isoform X1

      UniProtKB/TrEMBL
      F1MHS5
      Related
      ENSBTAP00000008523.6, ENSBTAT00000008523.7
      Conserved Domains (1) summary
      cd05030
      Location:6 → 94
      calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28783.3 GenPept UniProtKB/Swiss-Prot:P28783

    Gene LinkOut

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