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    ATP5ME ATP synthase membrane subunit e [ Homo sapiens (human) ]

    Gene ID: 521, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ATP5MEprovided by HGNC
    Official Full Name
    ATP synthase membrane subunit eprovided by HGNC
    Primary source
    HGNC:HGNC:846
    See related
    Ensembl:ENSG00000169020 MIM:601519; AllianceGenome:HGNC:846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATP5I; ATP5K
    Summary
    Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in colon (RPKM 167.6), kidney (RPKM 153.1) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ATP5ME in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (672436..674276, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (672110..673950, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (666225..668065, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:581897-583096 Neighboring gene uncharacterized LOC124900162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:604697-605456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:617058-618048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:619038-620027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:620028-621016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:628544-629044 Neighboring gene phosphodiesterase 6B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:644363-645316 Neighboring gene PDE6B antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:657162-657754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:668197-668954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:674515-675154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21131 Neighboring gene solute carrier family 49 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21132 Neighboring gene myosin light chain 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:680358-681306 Neighboring gene uncharacterized LOC124900643

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm. Hase Y, et al. Biochem Biophys Res Commun, 2008 Feb 1. PMID 18060860
    2. Antisense of ATP synthase subunit e inhibits the growth of human hepatocellular carcinoma cells. Ying H, et al. Oncol Res, 2001. PMID 11939412
    3. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
    4. F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes. Papathanassiu AE, et al. Biochem Biophys Res Commun, 2006 Jun 23. PMID 16682002
    5. Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review). Leyva JA, et al. Mol Membr Biol, 2003 Jan-Mar. PMID 12745923

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    2. The inhibitory activity against mitochondria and F(1)F(0)-ATP synthase is not limited to atrazine but is likely to be applicable to other triazine-based compounds.
      Title: Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm.
    3. results suggest that antisense of hAS-e can inhibit cell proliferation through the MAP kinase pathway
      Title: Antisense of ATP synthase subunit e inhibits the growth of human hepatocellular carcinoma cells.
    4. This is the first report identifying caspase-3 as a substrate protein of Hsp90.
      Title: F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (ATP5I) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC12532

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit e, mitochondrial
    Names
    ATP synthase e chain, mitochondrial
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E
    ATP synthase, H+ transporting, mitochondrial Fo complex subunit E
    ATPase subunit e
    F1F0-ATP synthase, murine e subunit
    NP_009031.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007100.4 → NP_009031.1  ATP synthase subunit e, mitochondrial

      See identical proteins and their annotated locations for NP_009031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BC003679, BF215596, BG940181
      Consensus CDS
      CCDS3337.1
      UniProtKB/Swiss-Prot
      P56385, Q0D2L9
      Related
      ENSP00000306003.4, ENST00000304312.5
      Conserved Domains (1) summary
      pfam05680
      Location:2 → 69
      ATP-synt_E; ATP synthase E chain

    RNA

    1. NR_033743.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BG940181, DA119852
      Related
      ENST00000505852.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      672436..674276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      672110..673950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56385.2 GenPept UniProtKB/Swiss-Prot:P56385

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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