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    KLF4 KLF transcription factor 4 [ Bos taurus (cattle) ]

    Gene ID: 520842, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KLF4provided by VGNC
    Official Full Name
    KLF transcription factor 4provided by VGNC
    Primary source
    VGNC:VGNC:52790
    See related
    BGD:BT16667; Ensembl:ENSBTAG00000020355
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See KLF4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (97174495..97179299, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene RAD23 homolog B, nucleotide excision repair protein Neighboring gene uncharacterized LOC104969469 Neighboring gene uncharacterized LOC107132732 Neighboring gene uncharacterized LOC132346001

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncoupled embryonic and extra-embryonic tissues compromise blastocyst development after somatic cell nuclear transfer. Degrelle SA, et al. PLoS One, 2012. PMID 22701625, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC139189

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Krueppel-like factor 4
    Names
    Kruppel like factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105385.1 → NP_001098855.1  Krueppel-like factor 4

      See identical proteins and their annotated locations for NP_001098855.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134523
      UniProtKB/TrEMBL
      A7YWE2, F1MP32
      Conserved Domains (4) summary
      COG5048
      Location:389 → 472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:396 → 418
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394 → 418
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:440 → 465
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      97174495..97179299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005210496.5 → XP_005210553.1  Krueppel-like factor 4 isoform X2

      UniProtKB/TrEMBL
      A0A3S5ZPR3
      Related
      ENSBTAP00000027125.6, ENSBTAT00000027125.7
      Conserved Domains (4) summary
      COG5048
      Location:398 → 481
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:405 → 427
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:403 → 427
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:449 → 474
      zf-H2C2_2; Zinc-finger double domain

    2. XM_005210495.5 → XP_005210552.1  Krueppel-like factor 4 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:431 → 514
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 460
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:436 → 460
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:482 → 507
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials