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    LARP7 La ribonucleoprotein 7, transcriptional regulator [ Homo sapiens (human) ]

    Gene ID: 51574, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LARP7provided by HGNC
    Official Full Name
    La ribonucleoprotein 7, transcriptional regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:24912
    See related
    Ensembl:ENSG00000174720 MIM:612026; AllianceGenome:HGNC:24912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALAZS; PIP7S; hLARP7; HDCMA18P
    Summary
    This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in lymph node (RPKM 17.7), thyroid (RPKM 16.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LARP7 in Genome Data Viewer
    Location:
    4q25
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (112637143..112657586)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (115945482..115965926)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113558299..113578742)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NEUROG2 and ZGRF1 antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 94 Neighboring gene zinc finger GRF-type containing 1 Neighboring gene H3 histone pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21833 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:113564861-113564962 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:113570027-113570749 Neighboring gene miR-302/367 cluster host gene Neighboring gene microRNA 302d Neighboring gene microRNA 302a Neighboring gene microRNA 302c Neighboring gene microRNA 302b Neighboring gene microRNA 367 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:113604501-113604662 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene GET1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LARP7 is a potential tumor suppressor gene in gastric cancer. Cheng Y, et al. Lab Invest, 2012 Jul. PMID 22488152, Free PMC Article
    2. LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway. Sui X, et al. Mol Med Rep, 2018 Jun. PMID 29620212, Free PMC Article
    3. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. Tyagi M, et al. J Virol, 2010 Jul. PMID 20410271, Free PMC Article
    4. Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome. Gana S, et al. Am J Med Genet A, 2020 Nov. PMID 32888391
    5. Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. Holohan B, et al. BMC Genomics, 2016 Oct 17. PMID 27766953, Free PMC Article

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis.
      Title: LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis.
    2. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
      Title: LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
    3. Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.
      Title: Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.
    4. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.
      Title: LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis.
    5. Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
      Title: Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
    6. Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism.
      Title: Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism.
    7. Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood.
      Title: Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood.
    8. Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome.
      Title: Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome.
    9. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.
      Title: L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.
    10. LARP7 functios as a bridging factor for snoRNA-guided modification of the U6 snRNA and alterations in splicing fidelity contribute to the etiology of the Alazami syndrome.
      Title: The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Microcephalic primordial dwarfism, Alazami type
    MedGen: C3554439 OMIM: 615071 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
    tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed
    tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
    tat CDK9-CycT1-AFF1 is stimulated by HIV-1 Tat and transferred as a single complex unit to BRD4 upon stress-induced disruption of AFF1-containing 7SK snRNP (HEXIM1, MEPCE, LARP7, 7SK RNA, CDK9, CycT1, and AFF1) PubMed
    tat TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase PubMed
    tat HIV-1 Tat is identified to have a physical interaction with La ribonucleoprotein domain family, member 7 (LARP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC104360, DKFZp564K112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 7SK snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables U6 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U6 2'-O-snRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in box C/D sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription elongation by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of viral transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of snRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 7SK snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    la-related protein 7
    Names
    La ribonucleoprotein domain family member 7
    P-TEFb-interaction protein for 7SK stability

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032779.1 RefSeqGene

      Range
      5180..25623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267039.4 → NP_001253968.2  la-related protein 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3 and 9 encode the same isoform (1).
      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS3701.2
      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
      UniProtKB/TrEMBL
      A0A8Q3SHF1
      Related
      ENSP00000422626.2, ENST00000509061.5
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:454 → 535
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

    2. NM_001370974.1 → NP_001357903.1  la-related protein 7 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93568.1
      UniProtKB/TrEMBL
      A0A8Q3SHG9, A0A8Q3SHN7
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:467 → 565
      RRM_3; RNA binding motif

    3. NM_001370975.1 → NP_001357904.1  la-related protein 7 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93568.1
      UniProtKB/TrEMBL
      A0A8Q3SHG9, A0A8Q3SHN7
      Related
      ENSP00000511576.1, ENST00000694898.1
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:467 → 565
      RRM_3; RNA binding motif

    4. NM_001370976.1 → NP_001357905.1  la-related protein 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93569.1
      UniProtKB/TrEMBL
      A0A8Q3SHG9, H0YA82
      Related
      ENSP00000426376.2, ENST00000511529.2
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 299
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:466 → 564
      RRM_3; RNA binding motif

    5. NM_001370977.1 → NP_001357906.1  la-related protein 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93569.1
      UniProtKB/TrEMBL
      A0A8Q3SHG9, H0YA82
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 299
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:466 → 564
      RRM_3; RNA binding motif

    6. NM_001370978.1 → NP_001357907.1  la-related protein 7 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS3701.2
      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
      UniProtKB/TrEMBL
      A0A8Q3SHF1
      Related
      ENSP00000499190.1, ENST00000651579.1
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:454 → 535
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

    7. NM_001370979.1 → NP_001357908.1  la-related protein 7 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93570.1
      UniProtKB/TrEMBL
      A0A8Q3SHF1, A0A8Q3SHH4
      Related
      ENSP00000511571.1, ENST00000694891.1
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 299
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:453 → 551
      RRM_3; RNA binding motif

    8. NM_001370980.1 → NP_001357909.1  la-related protein 7 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93570.1
      UniProtKB/TrEMBL
      A0A8Q3SHF1, A0A8Q3SHH4
      Related
      ENSP00000511577.1, ENST00000694899.1
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 299
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:453 → 551
      RRM_3; RNA binding motif

    9. NM_001370981.1 → NP_001357910.1  la-related protein 7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93571.1
      UniProtKB/TrEMBL
      A0A8I5KUI4, A0A8Q3SHF1
      Related
      ENSP00000508585.1, ENST00000693375.1
      Conserved Domains (4) summary
      COG0724
      Location:38 → 221
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:47 → 126
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:375 → 473
      RRM_3; RNA binding motif
      cl02755
      Location:1 → 32
      LAM; LA motif RNA-binding domain

    10. NM_001370982.1 → NP_001357911.1  la-related protein 7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC106864
      Consensus CDS
      CCDS93571.1
      UniProtKB/TrEMBL
      A0A8I5KUI4, A0A8Q3SHF1
      Related
      ENSP00000509527.1, ENST00000692416.1
      Conserved Domains (4) summary
      COG0724
      Location:38 → 221
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:47 → 126
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:375 → 473
      RRM_3; RNA binding motif
      cl02755
      Location:1 → 32
      LAM; LA motif RNA-binding domain

    11. NM_015454.3 → NP_056269.1  la-related protein 7 isoform 1

      See identical proteins and their annotated locations for NP_056269.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a 5' exon compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
      Source sequence(s)
      AL049996, BM979591, CA314598, CN346208
      Consensus CDS
      CCDS3701.2
      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
      UniProtKB/TrEMBL
      A0A8Q3SHF1
      Related
      ENSP00000421541.2, ENST00000505034.6
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:454 → 535
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

    12. NM_016648.4 → NP_057732.2  la-related protein 7 isoform 1

      See identical proteins and their annotated locations for NP_057732.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks two 5' exons compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
      Source sequence(s)
      AC106864, AK000274, AL049996, DB270203
      Consensus CDS
      CCDS3701.2
      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
      UniProtKB/TrEMBL
      A0A8Q3SHF1
      Related
      ENSP00000344950.5, ENST00000344442.10
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:454 → 535
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      112637143..112657586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415769.1 → XP_047271725.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SHN7

    2. XM_047415771.1 → XP_047271727.1  la-related protein 7 isoform X2

      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

    3. XM_024454083.2 → XP_024309851.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SHG9, A0A8Q3SHN7
      Conserved Domains (4) summary
      cd08032
      Location:30 → 111
      LARP_7; La RNA-binding domain of La-related protein 7
      COG0724
      Location:117 → 300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12290
      Location:126 → 205
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:467 → 565
      RRM_3; RNA binding motif

    4. XM_047415770.1 → XP_047271726.1  la-related protein 7 isoform X2

      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

    5. XM_047415768.1 → XP_047271724.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SHN7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      115945482..115965926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350164.1 → XP_054206139.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SHN7

    2. XM_054350166.1 → XP_054206141.1  la-related protein 7 isoform X2

      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

    3. XM_054350162.1 → XP_054206137.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SHN7

    4. XM_054350165.1 → XP_054206140.1  la-related protein 7 isoform X2

      UniProtKB/Swiss-Prot
      B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8

    5. XM_054350163.1 → XP_054206138.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8Q3SHN7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G0J3.1 GenPept UniProtKB/Swiss-Prot:Q4G0J3

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