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    GUSB glucuronidase beta [ Bos taurus (domestic cattle) ]

    Gene ID: 515687, updated on 4-Oct-2024

    Summary

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    Gene symbol
    GUSB
    Gene description
    glucuronidase beta
    See related
    BGD:BT22124; Ensembl:ENSBTAG00000000704
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GUSB in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (27906362..27918749, complement)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene elongin-B-like Neighboring gene vitamin K epoxide reductase complex subunit 1 like 1 Neighboring gene beta-glucuronidase-like Neighboring gene argininosuccinate lyase Neighboring gene CGRP receptor component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annexin VI is a mannose-6-phosphate-independent endocytic receptor for bovine β-glucuronidase. Ramírez-Mata A, et al. Exp Cell Res, 2011 Oct 1. PMID 21672540
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AnxA6 is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase.
      Title: Annexin VI is a mannose-6-phosphate-independent endocytic receptor for bovine β-glucuronidase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC155160

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables beta-glucuronidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-glucuronidase
    NP_001076905.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083436.1 → NP_001076905.1  beta-glucuronidase precursor

      See identical proteins and their annotated locations for NP_001076905.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133415
      UniProtKB/TrEMBL
      A0A3Q1LMC1, A3KMY8
      Related
      ENSBTAP00000000941.3, ENSBTAT00000000941.4
      Conserved Domains (4) summary
      PRK10150
      Location:28 → 631
      PRK10150; beta-D-glucuronidase; Provisional
      pfam00703
      Location:226 → 327
      Glyco_hydro_2; Glycosyl hydrolases family 2
      pfam02836
      Location:329 → 631
      Glyco_hydro_2_C; Glycosyl hydrolases family 2, TIM barrel domain
      pfam02837
      Location:37 → 224
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27906362..27918749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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