U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    OSER1 oxidative stress responsive serine rich 1 [ Homo sapiens (human) ]

    Gene ID: 51526, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    OSER1provided by HGNC
    Official Full Name
    oxidative stress responsive serine rich 1provided by HGNC
    Primary source
    HGNC:HGNC:16105
    See related
    Ensembl:ENSG00000132823 AllianceGenome:HGNC:16105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Osr1; Perit1; HSPC207; C20orf111; dJ1183I21.1
    Summary
    Predicted to be involved in cellular response to hydrogen peroxide. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in testis (RPKM 25.7), bone marrow (RPKM 22.5) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See OSER1 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44195939..44211810, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45930565..45949078, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42824579..42839411, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TOX high mobility group box family member 2 Neighboring gene RNA, 7SL, cytoplasmic 443, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42696545-42697061 Neighboring gene Sharpr-MPRA regulatory region 7745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42739928-42740441 Neighboring gene Sharpr-MPRA regulatory region 3924 Neighboring gene junctophilin 2 Neighboring gene uncharacterized LOC124904909 Neighboring gene JPH2 intron CAGE-defined T cell enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42795218-42795478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42806021-42806521 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:42809003-42809909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42810816-42811722 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:42832370-42833569 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42838821-42839440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12940 Neighboring gene OSER1 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42860439-42861068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42875650-42876448 Neighboring gene Sharpr-MPRA regulatory region 13448 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:42900885-42901394 Neighboring gene ganglioside induced differentiation associated protein 1 like 1 Neighboring gene Sharpr-MPRA regulatory region 2613 Neighboring gene uncharacterized LOC124904910

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. TargetLink, a new method for identifying the endogenous target set of a specific microRNA in intact living cells. Xu Y, et al. RNA Biol, 2017 Feb. PMID 27982722, Free PMC Article
    2. Cardiac myocyte gene expression profiling during H2O2-induced apoptosis. Clerk A, et al. Physiol Genomics, 2007 Apr 24. PMID 17148688
    3. Agrin has a pathological role in the progression of oral cancer. Rivera C, et al. Br J Cancer, 2018 Jun. PMID 29872149, Free PMC Article
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
    5. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    oxidative stress-responsive serine-rich protein 1
    Names
    oxidative stress-responsive 1
    oxidative stress-responsive protein 1
    peroxide-inducible transcript 1 protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016470.8 → NP_057554.4  oxidative stress-responsive serine-rich protein 1

      See identical proteins and their annotated locations for NP_057554.4

      Status: VALIDATED

      Source sequence(s)
      AL035447, BC064973, BF109349, BI462161
      Consensus CDS
      CCDS13327.1
      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Related
      ENSP00000255174.2, ENST00000255174.3
      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      44195939..44211810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027873.2 → XP_016883362.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    2. XM_011528854.4 → XP_011527156.1  oxidative stress-responsive serine-rich protein 1 isoform X2

      Conserved Domains (1) summary
      pfam05604
      Location:1 → 137
      DUF776; Protein of unknown function (DUF776)

    3. XM_047440191.1 → XP_047296147.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8

    4. XM_047440193.1 → XP_047296149.1  oxidative stress-responsive serine-rich protein 1 isoform X2

    5. XM_047440190.1 → XP_047296146.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8

    6. XM_047440192.1 → XP_047296148.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Related
      ENSP00000362061.1, ENST00000372970.6

    7. XM_011528853.4 → XP_011527155.1  oxidative stress-responsive serine-rich protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011527155.1

      UniProtKB/Swiss-Prot
      B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
      Conserved Domains (1) summary
      pfam05604
      Location:1 → 175
      DUF776; Protein of unknown function (DUF776)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      45930565..45949078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323485.1 → XP_054179460.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    2. XM_054323488.1 → XP_054179463.1  oxidative stress-responsive serine-rich protein 1 isoform X2

    3. XM_054323486.1 → XP_054179461.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    4. XM_054323484.1 → XP_054179459.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    5. XM_054323487.1 → XP_054179462.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    6. XM_054323489.1 → XP_054179464.1  oxidative stress-responsive serine-rich protein 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NX31.2 GenPept UniProtKB/Swiss-Prot:Q9NX31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools