ZNF589 zinc finger protein 589 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF589provided by HGNC
Official Full Name: zinc finger protein 589provided by HGNC
Primary source: HGNC:HGNC:16747
See related: Ensembl:ENSG00000164048 MIM:616702; AllianceGenome:HGNC:16747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SZF1
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thyroid (RPKM 4.8), prostate (RPKM 4.7) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 3p21.31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (48241104..48270990)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (48268885..48298764)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (48282594..48312480)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A heterochromatin inducing protein differentially recognizes self versus foreign genomes.
Title: A heterochromatin inducing protein differentially recognizes self versus foreign genomes.
The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system
Title: The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-33980 (e-PCR)
- UniSTS:24931

SHGC-76947 (e-PCR)
- UniSTS:55974

NoName (e-PCR)
- UniSTS:482779

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 589

Names: KRAB-zinc finger protein SZF1-1; stem cell zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016089.3 → NP_057173.2 zinc finger protein 589

See identical proteins and their annotated locations for NP_057173.2

Status: VALIDATED

Source sequence(s)

AC104190, AY258146

Consensus CDS

CCDS43085.1

UniProtKB/Swiss-Prot

Q86UC9, Q86UQ0, Q9BRI6, Q9BRY3, Q9Y611, Q9Y612

Related

ENSP00000346729.3, ENST00000354698.8

Conserved Domains (6) summary

smart00349
Location:35 → 84

KRAB; krueppel associated box

COG5048
Location:302 → 364

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:250 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:249 → 270

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:35 → 74

KRAB; KRAB box

pfam13465
Location:291 → 315

zf-H2C2_2; Zinc-finger double domain