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    RHO rhodopsin [ Bos taurus (domestic cattle) ]

    Gene ID: 509933, updated on 4-Oct-2024

    Summary

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    Official Symbol
    RHOprovided by VGNC
    Official Full Name
    rhodopsinprovided by VGNC
    Primary source
    VGNC:VGNC:33942
    See related
    BGD:BT14158; Ensembl:ENSBTAG00000001310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RHO in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (56225120..56231448, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene plexin D1 Neighboring gene H1.8 linker histone Neighboring gene intraflagellar transport 122 Neighboring gene DNA-directed RNA polymerase II subunit RPB1-like Neighboring gene methyl-CpG binding domain 4, DNA glycosylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin. Hanson SM, et al. Proc Natl Acad Sci U S A, 2006 Mar 28. PMID 16547131, Free PMC Article
    2. The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin. Springael JY, et al. Cell Signal, 2007 Jul. PMID 17320349
    3. Stabilizing effect of Zn2+ in native bovine rhodopsin. Park PS, et al. J Biol Chem, 2007 Apr 13. PMID 17303564, Free PMC Article
    4. The all-trans-15-syn-retinal chromophore of metarhodopsin III is a partial agonist and not an inverse agonist. Mahalingam M, et al. Biochemistry, 2006 Dec 26. PMID 17176084
    5. Functional reconstitution of rhodopsin into tubular lipid bilayers supported by nanoporous media. Soubias O, et al. Biochemistry, 2006 Dec 26. PMID 17176079

    See all (175) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations.
      Title: New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations.
    2. Simple Models to Study Spectral Properties of Microbial and Animal Rhodopsins: Evaluation of the Electrostatic Effect of Charged and Polar Residues on the First Absorption Band Maxima.
      Title: Simple Models to Study Spectral Properties of Microbial and Animal Rhodopsins: Evaluation of the Electrostatic Effect of Charged and Polar Residues on the First Absorption Band Maxima.
    3. Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness.
      Title: Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness.
    4. Conformational perturbation, allosteric modulation of cellular signaling pathways, and disease in P23H rhodopsin.
      Title: Conformational perturbation, allosteric modulation of cellular signaling pathways, and disease in P23H rhodopsin.
    5. Data suggest functionality for mutant R171 in stabilizing the inactive arrestin-1 conformation as well as the rhodopsin-arrestin-1 complex.
      Title: Arrestin-1 engineering facilitates complex stabilization with native rhodopsin.
    6. The density map reveals the receptor C-terminal tail bound to the Gbeta subunit of the G protein, providing a structural foundation for the role of the C-terminal tail in GPCR signaling, and of Gbeta as scaffold for recruiting Galpha subunits and G protein-receptor kinases.
      Title: Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit.
    7. the binding of flavonoids to an RP-linked P23H opsin variant partially restored its normal cellular trafficking.
      Title: Flavonoids enhance rod opsin stability, folding, and self-association by directly binding to ligand-free opsin and modulating its conformation.
    8. Crystal structure of rhodopsin bound to an engineered mini-Go protein reveals that rhodopsin seems to adopt predominantly one thermodynamically stable active conformation.
      Title: Crystal structure of rhodopsin in complex with a mini-G(o) sheds light on the principles of G protein selectivity.
    9. Lipids Alter Rhodopsin Function via Ligand-like and Solvent-like Interactions
      Title: Lipids Alter Rhodopsin Function via Ligand-like and Solvent-like Interactions.
    10. Data indicate molecular dynamics simulations and site-directed fluorescence experiments on arrestin-1 interactions with rhodopsin, showing that loops within the C-edge of arrestin function as a membrane anchor.
      Title: C-edge loops of arrestin function as a membrane anchor.
    Submit: New GeneRIF Correction See all GeneRIFs (137)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phototransduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhodopsin
    Names
    rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014890.2 → NP_001014890.1  rhodopsin

      See identical proteins and their annotated locations for NP_001014890.1

      Status: VALIDATED

      Source sequence(s)
      DAAA02054571
      UniProtKB/Swiss-Prot
      P02699
      Related
      ENSBTAP00000001730.5, ENSBTAT00000001730.7
      Conserved Domains (2) summary
      pfam10413
      Location:3 → 37
      Rhodopsin_N; Amino terminal of the G-protein receptor rhodopsin
      cd15080
      Location:38 → 317
      7tmA_MWS_opsin; medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56225120..56231448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02699.1 GenPept UniProtKB/Swiss-Prot:P02699

    Gene LinkOut

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