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    Hpcal4 hippocalcin-like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50872, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hpcal4provided by RGD
    Official Full Name
    hippocalcin-like 4provided by RGD
    Primary source
    RGD:708491
    See related
    EnsemblRapid:ENSRNOG00000050983 AllianceGenome:RGD:708491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NVL-2; NVP-2; Nvjp2; VILIP-2
    Summary
    Enables calcium channel regulator activity and protein domain specific binding activity. Predicted to be involved in regulation of signal transduction. Orthologous to human HPCAL4 (hippocalcin like 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 332.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hpcal4 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140739577..140751529)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135454477..135466417)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140870127..140882242)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 8b Neighboring gene peptidylprolyl isomerase E Neighboring gene uncharacterized LOC134486987 Neighboring gene uncharacterized LOC120102973 Neighboring gene 5'-nucleotidase, cytosolic IA Neighboring gene uncharacterized LOC108351027 Neighboring gene hes-related family bHLH transcription factor with YRPW motif-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of two additional members of the neural visinin-like Ca(2+)-binding protein gene family. Kajimoto Y, et al. J Neurochem, 1993 Sep. PMID 8360675
    2. Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. Okazaki K, et al. Biochem Biophys Res Commun, 1992 May 29. PMID 1599450
    3. Differential regulation of CaV2.1 channels by calcium-binding protein 1 and visinin-like protein-2 requires N-terminal myristoylation. Few AP, et al. J Neurosci, 2005 Jul 27. PMID 16049184, Free PMC Article
    4. cDNA cloning of a neural visinin-like Ca(2+)-binding protein. Kuno T, et al. Biochem Biophys Res Commun, 1992 May 15. PMID 1375457
    5. Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus. Kobayashi M, et al. Biochem Biophys Res Commun, 1992 Nov 30. PMID 1280427

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hippocalcin-like protein 4
    Names
    neural visinin-like Ca2+-binding protein type 2
    neural visinin-like protein 2
    visinin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429861.1 → NP_001416790.1  hippocalcin-like protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P35332
      UniProtKB/TrEMBL
      A6IS20

    2. NM_017357.2 → NP_059053.1  hippocalcin-like protein 4

      See identical proteins and their annotated locations for NP_059053.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P35332
      UniProtKB/TrEMBL
      A6IS20
      Conserved Domains (1) summary
      COG5126
      Location:13 → 181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      140739577..140751529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238829.5 → XP_006238891.1  hippocalcin-like protein 4 isoform X1

      Related
      ENSRNOP00000066655.1, ENSRNOT00000074347.4
      Conserved Domains (1) summary
      COG5126
      Location:13 → 181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35332.2 GenPept UniProtKB/Swiss-Prot:P35332

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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