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    PNPLA2 patatin like phospholipase domain containing 2 [ Bos taurus (cattle) ]

    Gene ID: 508493, updated on 4-Jun-2024

    Summary

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    Official Symbol
    PNPLA2provided by VGNC
    Official Full Name
    patatin like phospholipase domain containing 2provided by VGNC
    Primary source
    VGNC:VGNC:33091
    See related
    BGD:BT11983; Ensembl:ENSBTAG00000005144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ATGL
    Orthologs
    human mouse all
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    Genomic context

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    See PNPLA2 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (50548339..50553115, complement)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene CD151 molecule Neighboring gene basic proline-rich protein Neighboring gene calcium release activated channel regulator 2B Neighboring gene small nucleolar RNA SNORA52 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene p53-induced death domain protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bovine adipose triglyceride lipase is not altered and adipocyte fatty acid-binding protein is increased by dietary flaxseed. Deiuliis J, et al. Lipids, 2010 Nov. PMID 20886305
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.
      Title: Bovine adipose triglyceride lipase is not altered and adipocyte fatty acid-binding protein is increased by dietary flaxseed.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC137478

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables triglyceride lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    patatin-like phospholipase domain-containing protein 2
    Names
    adipose triglyceride lipase
    calcium-independent phospholipase A2-zeta
    iPLA2-zeta
    NP_001039470.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046005.2 → NP_001039470.1  patatin-like phospholipase domain-containing protein 2

      See identical proteins and their annotated locations for NP_001039470.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112803
      UniProtKB/Swiss-Prot
      Q2KI18
      UniProtKB/TrEMBL
      C1K6G4, D6BQM3
      Related
      ENSBTAP00000029866.2, ENSBTAT00000029870.4
      Conserved Domains (1) summary
      cd07220
      Location:5 → 252
      Pat_PNPLA2; Patatin-like phospholipase domain containing protein 2

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50548339..50553115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KI18.1 GenPept UniProtKB/Swiss-Prot:Q2KI18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials