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    ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 508356, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ITIH1provided by VGNC
    Official Full Name
    inter-alpha-trypsin inhibitor heavy chain 1provided by VGNC
    Primary source
    VGNC:VGNC:30334
    See related
    BGD:BT17600; Ensembl:ENSBTAG00000007843
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ITIH1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (48099219..48113463, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene NIMA related kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140532

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H1
    Names
    ITI heavy chain H1
    ITI-HC1
    inter-alpha (globulin) inhibitor H1
    inter-alpha-inhibitor heavy chain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075353.2 → NP_001068821.1  inter-alpha-trypsin inhibitor heavy chain H1 precursor

      See identical proteins and their annotated locations for NP_001068821.1

      Status: PROVISIONAL

      Source sequence(s)
      BC120096
      UniProtKB/Swiss-Prot
      Q0VCM5
      UniProtKB/TrEMBL
      A0A3Q1LVM5
      Related
      ENSBTAP00000064694.2, ENSBTAT00000083503.2
      Conserved Domains (3) summary
      smart00609
      Location:35 → 161
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:286 → 465
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      pfam06668
      Location:700 → 887
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48099219..48113463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VCM5.1 GenPept UniProtKB/Swiss-Prot:Q0VCM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials