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    SCAP SREBF chaperone [ Bos taurus (domestic cattle) ]

    Gene ID: 507878, updated on 10-Oct-2024

    Summary

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    Official Symbol
    SCAPprovided by VGNC
    Official Full Name
    SREBF chaperoneprovided by VGNC
    Primary source
    VGNC:VGNC:34320
    See related
    BGD:BT11994; Ensembl:ENSBTAG00000015782
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SCAP in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (52163455..52263264)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene uncharacterized LOC112443483 Neighboring gene U6 spliceosomal RNA Neighboring gene protein tyrosine phosphatase non-receptor type 23 Neighboring gene uncharacterized LOC132343519 Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells. Han L, et al. Prostaglandins Other Lipid Mediat, 2020 Aug. PMID 31953015
    2. PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells. Su BQ, et al. Biotechnol Lett, 2018 Apr. PMID 29383471
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells.
      Title: Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells.
    2. Although the knockdown of PKM2 had no effect on MAC-T cell growth, the reduced expression of PKM2 attenuated the mRNA and protein expression of key enzymes involved in sterol synthesis through the SREBP pathway.
      Title: PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC157202

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sterol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sterol regulatory element-binding protein cleavage-activating protein
    Names
    SREBP cleavage-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101889.1 → NP_001095359.1  sterol regulatory element-binding protein cleavage-activating protein

      See identical proteins and their annotated locations for NP_001095359.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148152
      UniProtKB/Swiss-Prot
      A6QM06
      UniProtKB/TrEMBL
      F1MQ33
      Related
      ENSBTAP00000020961.6, ENSBTAT00000020961.7
      Conserved Domains (4) summary
      COG2319
      Location:1076 → 1234
      WD40; WD40 repeat [General function prediction only]
      pfam12349
      Location:308 → 457
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      sd00039
      Location:958 → 1004
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:1077 → 1234
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      52163455..52263264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059879557.1 → XP_059735540.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    2. XM_059879558.1 → XP_059735541.1  sterol regulatory element-binding protein cleavage-activating protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6QM06.1 GenPept UniProtKB/Swiss-Prot:A6QM06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials