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    Mapk6 mitogen-activated protein kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 50772, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mapk6provided by MGI
    Official Full Name
    mitogen-activated protein kinase 6provided by MGI
    Primary source
    MGI:MGI:1354946
    See related
    Ensembl:ENSMUSG00000042688 AllianceGenome:MGI:1354946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erk3; Mapk4; Prkm4; Prkm6; Mapk63; 2610021I23Rik; D130053K17Rik
    Summary
    Enables MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Involved in protein phosphorylation. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin cytoskeleton. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 62.3), CNS E11.5 (RPKM 31.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mapk6 in Genome Data Viewer
    Location:
    9 D; 9 42.3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75294064..75317303, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75386782..75410016, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24661 Neighboring gene zygote arrest 1-like pseudogene Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24662 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:75249977-75250086 Neighboring gene STARR-positive B cell enhancer ABC_E11414 Neighboring gene RIKEN cDNA 4933433G15 gene Neighboring gene STARR-positive B cell enhancer ABC_E3844 Neighboring gene STARR-positive B cell enhancer ABC_E6767 Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene STARR-seq mESC enhancer starr_24669 Neighboring gene predicted gene, 57538

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The atypical MAPK ERK3 controls positive selection of thymocytes. Sirois J, et al. Immunology, 2015 May. PMID 25521218, Free PMC Article
    2. ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis. Li S, et al. PLoS One, 2010 Sep 29. PMID 20927325, Free PMC Article
    3. Targeting ERK3/MK5 complex for treatment of obesity and diabetes. Loza-Valdes A, et al. Biochem Biophys Res Commun, 2022 Jul 5. PMID 35523049
    4. Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy. Yao T, et al. Gene, 2020 Jul 15. PMID 32275999
    5. The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. El-Merahbi R, et al. Genes Dev, 2020 Apr 1. PMID 32139423, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. circ_0000285 promoted podocyte injury via sponging miR-654-3p and activating MAPK6 in diabetic nephropathy.
      Title: Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy.
    2. Results show that Cdo is important for full Abl kinase activity, and Abl is necessary for full activation of p38 MAPK, during myogenic differentiation.
      Title: Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation.
    3. Data show that extracellular-regulated kinase 3 (ERK3) specifically interacts with the MAPK-activated protein kinase 5 (MK5 or PRAK) in vitro and in vivo.
      Title: Scaffolding by ERK3 regulates MK5 in development.
    4. p38gamma MAP kinase (SAPK3/p38gamma) was shown to catalyse phosphorylation of SAP97.
      Title: p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.
    5. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability
      Title: Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
    6. Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5).
      Title: Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 6
    Names
    Erk-3 related
    MAP kinase 6
    extracellular signal-regulated kinase 3
    mitogen activated protein kinase 4
    protein kinase, mitogen activated kinase 4
    NP_056621.4
    NP_081694.1
    XP_011241069.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015806.5 → NP_056621.4  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_056621.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC115880, AK051508, BC048779, BC100385, CA325060
      Consensus CDS
      CCDS23342.1
      UniProtKB/Swiss-Prot
      Q497T9, Q61532, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6
      Related
      ENSMUSP00000040315.11, ENSMUST00000049355.11
      Conserved Domains (1) summary
      cd07854
      Location:14 → 355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    2. NM_027418.2 → NP_081694.1  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_081694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC115880, AK051508, BC048779, BC100385, BY737145
      Consensus CDS
      CCDS23342.1
      UniProtKB/Swiss-Prot
      Q497T9, Q61532, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6
      Related
      ENSMUSP00000129024.2, ENSMUST00000168937.8
      Conserved Domains (1) summary
      cd07854
      Location:14 → 355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      75294064..75317303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242767.4 → XP_011241069.1  mitogen-activated protein kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_011241069.1

      UniProtKB/Swiss-Prot
      Q497T9, Q61532, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6
      Conserved Domains (1) summary
      cd07854
      Location:14 → 355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61532.3 GenPept UniProtKB/Swiss-Prot:Q61532

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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