REG3A regenerating family member 3 alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: REG3Aprovided by HGNC
Official Full Name: regenerating family member 3 alphaprovided by HGNC
Primary source: HGNC:HGNC:8601
See related: Ensembl:ENSG00000172016 MIM:167805; AllianceGenome:HGNC:8601
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
Summary: This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
Expression: Biased expression in small intestine (RPKM 2111.4) and duodenum (RPKM 1539.8) See more
Orthologs: all
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Genomic context

Location:: 2p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (79157006..79159753, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (79157332..79160079, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (79384132..79386879, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells.
Title: Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells.
REG3A overexpression functions as a negative predictive and prognostic biomarker in rectal cancer patients receiving CCRT.
Title: REG3A overexpression functions as a negative predictive and prognostic biomarker in rectal cancer patients receiving CCRT.
REG3A promotes proliferation and DDP resistance of ovarian cancer cells by activating the PI3K/Akt signaling pathway.
Title: REG3A promotes proliferation and DDP resistance of ovarian cancer cells by activating the PI3K/Akt signaling pathway.
Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice.
Title: Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice.
Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2.
Title: Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2.
[Effect of REG3A on proliferation and invasion of glioma cells by regulating PI3K/Akt signaling pathway].
Title: [Effect of REG3A on proliferation and invasion of glioma cells by regulating PI3K/Akt signaling pathway].
Regenerating islet-derived protein 3-alpha is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease.
Title: Regenerating islet-derived protein 3-α is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease.
The regenerating protein 3A: a crucial molecular with dual roles in cancer.
Title: The regenerating protein 3A: a crucial molecular with dual roles in cancer.
Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer.
Title: Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer.
Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes.
Title: Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S2561 (e-PCR)
- UniSTS:8891

GDB:631913 (e-PCR)
- UniSTS:158442

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	TAS Traceable Author Statement more info	PubMed
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of detection of glucose	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of keratinocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of wound healing	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to symbiotic bacterium	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: regenerating islet-derived protein 3-alpha

Names: PAP homologous protein; REG-3-alpha; hepatocarcinoma-intestine-pancreas; hepatointestinal pancreatic protein; human proislet peptide; pancreatic beta cell growth factor; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; reg III-alpha; regenerating islet-derived 3 alpha; regenerating islet-derived protein III-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029902.1 RefSeqGene

Range

5002..7749

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002580.3 → NP_002571.1 regenerating islet-derived protein 3-alpha precursor

See identical proteins and their annotated locations for NP_002571.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the functional protein. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

BC036776, BQ777112

Consensus CDS

CCDS1965.1

UniProtKB/Swiss-Prot

Q06141

UniProtKB/TrEMBL

D6W5K0, Q53S56

Related

ENSP00000304311.2, ENST00000305165.3

Conserved Domains (1) summary

cd03594
Location:40 → 173

CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
NM_138937.3 → NP_620354.1 regenerating islet-derived protein 3-alpha precursor

See identical proteins and their annotated locations for NP_620354.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK291973, BC036776

Consensus CDS

CCDS1965.1

UniProtKB/Swiss-Prot

Q06141

UniProtKB/TrEMBL

D6W5K0, Q53S56

Related

ENSP00000386630.3, ENST00000409839.7

Conserved Domains (1) summary

cd03594
Location:40 → 173

CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
NM_138938.3 → NP_620355.1 regenerating islet-derived protein 3-alpha precursor

See identical proteins and their annotated locations for NP_620355.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AY544128, BC036776, DC300833

Consensus CDS

CCDS1965.1

UniProtKB/Swiss-Prot

Q06141

UniProtKB/TrEMBL

D6W5K0, Q53S56

Related

ENSP00000377456.1, ENST00000393878.5

Conserved Domains (1) summary

cd03594
Location:40 → 173

CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)