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    PDGFA platelet derived growth factor subunit A [ Bos taurus (domestic cattle) ]

    Gene ID: 505908, updated on 10-Oct-2024

    Summary

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    Official Symbol
    PDGFAprovided by VGNC
    Official Full Name
    platelet derived growth factor subunit Aprovided by VGNC
    Primary source
    VGNC:VGNC:32689
    See related
    Ensembl:ENSBTAG00000014541
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PDGFA in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (42009812..42030408)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112444333 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC101904836 Neighboring gene forkhead box L3 Neighboring gene FAM20C golgi associated secretory pathway kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor subunit A
    Names
    PDGF subunit A
    platelet-derived growth factor A chain
    platelet-derived growth factor alpha polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075231.1 → NP_001068699.1  platelet-derived growth factor subunit A precursor

      See identical proteins and their annotated locations for NP_001068699.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105569
      UniProtKB/Swiss-Prot
      Q2KJ15
      Related
      ENSBTAP00000019323.7, ENSBTAT00000019323.7
      Conserved Domains (2) summary
      smart00141
      Location:94 → 179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42009812..42030408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881190.1 → XP_059737173.1  platelet-derived growth factor subunit A isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0M6
      Related
      ENSBTAP00000090084.1, ENSBTAT00000121261.1

    2. XM_059881192.1 → XP_059737175.1  platelet-derived growth factor subunit A isoform X3

      UniProtKB/TrEMBL
      A0AAA9S4T8
      Related
      ENSBTAP00000080201.1, ENSBTAT00000107752.1

    3. XM_024984705.2 → XP_024840473.1  platelet-derived growth factor subunit A isoform X4

      UniProtKB/TrEMBL
      A0AAF6Z0H2
      Conserved Domains (2) summary
      smart00141
      Location:94 → 179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    4. XM_024984702.2 → XP_024840470.1  platelet-derived growth factor subunit A isoform X2

      UniProtKB/Swiss-Prot
      Q2KJ15
      Conserved Domains (2) summary
      smart00141
      Location:94 → 179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    5. XM_024984701.2 → XP_024840469.1  platelet-derived growth factor subunit A isoform X2

      UniProtKB/Swiss-Prot
      Q2KJ15
      Conserved Domains (2) summary
      smart00141
      Location:94 → 179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    6. XM_059881191.1 → XP_059737174.1  platelet-derived growth factor subunit A isoform X2

      UniProtKB/Swiss-Prot
      Q2KJ15

    7. XM_024984703.2 → XP_024840471.1  platelet-derived growth factor subunit A isoform X4

      UniProtKB/TrEMBL
      A0AAF6Z0H2
      Conserved Domains (2) summary
      smart00141
      Location:94 → 179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KJ15.1 GenPept UniProtKB/Swiss-Prot:Q2KJ15

    Gene LinkOut

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