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    DUXAP8 double homeobox A pseudogene 8 [ Homo sapiens (human) ]

    Gene ID: 503637, updated on 17-Sep-2024

    Summary

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    Official Symbol
    DUXAP8provided by HGNC
    Official Full Name
    double homeobox A pseudogene 8provided by HGNC
    Primary source
    HGNC:HGNC:32187
    See related
    Ensembl:ENSG00000206195 AllianceGenome:HGNC:32187
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 13.5), testis (RPKM 6.4) and 11 other tissues See more
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    Genomic context

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    See DUXAP8 in Genome Data Viewer
    Location:
    22q11.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (15784954..15827434)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (16358848..16401349)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (16150529..16193009, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene POTEH antisense RNA 1 Neighboring gene POTE ankyrin domain family member H Neighboring gene RNA, U6 small nuclear 816, pseudogene Neighboring gene prostate enriched lncRNA Neighboring gene GRAM domain containing 4 pseudogene 2 Neighboring gene OCT4 hESC enhancer GRCh37_chr22:16212624-16213125 Neighboring gene BMS1 pseudogene 22 Neighboring gene TOMM40 pseudogene 2 Neighboring gene neurobeachin pseudogene 3 Neighboring gene CMT1A duplicated region transcript 15 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Downregulated DUXAP8 lncRNA impedes trophoblast cell proliferation and migration by epigenetically upregulating TFPI2 expression. Tang X, et al. Reprod Biol Endocrinol, 2023 Jun 22. PMID 37349838, Free PMC Article
    2. The pseudogene derived long noncoding RNA DUXAP8 promotes gastric cancer cell proliferation and migration via epigenetically silencing PLEKHO1 expression. Ma HW, et al. Oncotarget, 2017 Aug 8. PMID 28881724, Free PMC Article
    3. Long non-coding RNA DUXAP8 regulates proliferation and invasion of esophageal squamous cell cancer. Xu LJ, et al. Eur Rev Med Pharmacol Sci, 2018 May. PMID 29771416
    4. LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway. Lei C, et al. Cancer Biol Ther, 2022 Dec 31. PMID 36329030, Free PMC Article
    5. The double homeobox a pseudogene 8 accelerates cell proliferation, migration, and invasion in colon cancer. Mao S, et al. Bioengineered, 2022 Apr. PMID 35287542, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal lncRNA DUXAP8 affecting CHPF2 in the pathogenesis of intracranial aneurysms.
      Title: Exosomal lncRNA DUXAP8 affecting CHPF2 in the pathogenesis of intracranial aneurysms.
    2. Downregulated DUXAP8 lncRNA impedes trophoblast cell proliferation and migration by epigenetically upregulating TFPI2 expression.
      Title: Downregulated DUXAP8 lncRNA impedes trophoblast cell proliferation and migration by epigenetically upregulating TFPI2 expression.
    3. DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating miR-18b-5p/HIF3A.
      Title: DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating miR-18b-5p/HIF3A.
    4. Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation.
      Title: Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation.
    5. LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway.
      Title: LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway.
    6. Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
      Title: Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
    7. DUXAP8: A Promising lncRNA with Carcinogenic Potential in Cancer.
      Title: DUXAP8: A Promising lncRNA with Carcinogenic Potential in Cancer.
    8. The double homeobox a pseudogene 8 accelerates cell proliferation, migration, and invasion in colon cancer.
      Title: The double homeobox a pseudogene 8 accelerates cell proliferation, migration, and invasion in colon cancer.
    9. Functions of lncRNA DUXAP8 in non-small cell lung cancer.
      Title: Functions of lncRNA DUXAP8 in non-small cell lung cancer.
    10. Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297.
      Title: Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    General gene information

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    Clone Names

    • FLJ31573

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_122113.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000525, AP000527
      Related
      ENST00000413768.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      15784954..15827434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      16358848..16401349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_004840.6: Suppressed sequence

      Description
      NG_004840.6: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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