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    Mis12 MIS12 kinetochore complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501706, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mis12provided by RGD
    Official Full Name
    MIS12 kinetochore complex componentprovided by RGD
    Primary source
    RGD:1564837
    See related
    EnsemblRapid:ENSRNOG00000066036 AllianceGenome:RGD:1564837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and kinetochore assembly. Predicted to be located in kinetochore and nucleus. Predicted to be part of MIS12/MIND type complex. Orthologous to human MIS12 (MIS12 kinetochore complex component). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 106.7), Lung (RPKM 90.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mis12 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (56238317..56246491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55739741..55747915)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57653685..57661833)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 33 Neighboring gene derlin 2 Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene RIKEN cDNA 6330403K07 gene like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. Goshima G, et al. J Cell Biol, 2003 Jan 6. PMID 12515822, Free PMC Article
    2. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Shrestha RL, et al. Curr Biol, 2013 Aug 19. PMID 23891108, Free PMC Article
    3. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. Kline SL, et al. J Cell Biol, 2006 Apr 10. PMID 16585270, Free PMC Article
    4. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Cheeseman IM, et al. Genes Dev, 2004 Sep 15. PMID 15371340, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MIS12/MIND type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MIS12/MIND type complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein MIS12 homolog
    Names
    MIS12, MIND kinetochore complex component, homolog
    liver regeneration-related protein LRRG112

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395047.1 → NP_001381976.1  protein MIS12 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four transcripts encode the same protein.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q7TQ72
      UniProtKB/TrEMBL
      A0A8I5ZNK5
      Related
      ENSRNOP00000079471.1, ENSRNOT00000106462.2
      Conserved Domains (1) summary
      pfam05859
      Location:8 → 140
      Mis12; Mis12 protein

    2. NM_001395048.1 → NP_001381977.1  protein MIS12 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q7TQ72
      UniProtKB/TrEMBL
      A0A8I5ZNK5
      Conserved Domains (1) summary
      pfam05859
      Location:8 → 140
      Mis12; Mis12 protein

    3. NM_001395049.1 → NP_001381978.1  protein MIS12 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q7TQ72
      UniProtKB/TrEMBL
      A0A8I5ZNK5
      Related
      ENSRNOP00000079828.1, ENSRNOT00000103227.2
      Conserved Domains (1) summary
      pfam05859
      Location:8 → 140
      Mis12; Mis12 protein

    4. NM_001395050.1 → NP_001381979.1  protein MIS12 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q7TQ72
      UniProtKB/TrEMBL
      A0A8I5ZNK5
      Conserved Domains (1) summary
      pfam05859
      Location:8 → 140
      Mis12; Mis12 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      56238317..56246491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047972.1: Suppressed sequence

      Description
      NM_001047972.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQ72.2 GenPept UniProtKB/Swiss-Prot:Q7TQ72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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