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    Ccdc134 coiled-coil domain containing 134 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500909, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc134provided by RGD
    Official Full Name
    coiled-coil domain containing 134provided by RGD
    Primary source
    RGD:1559657
    See related
    EnsemblRapid:ENSRNOG00000007262 AllianceGenome:RGD:1559657
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of ossification. Predicted to act upstream of or within several processes, including angiogenesis; embryonic organ development; and ventricular system development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in osteogenesis imperfecta. Orthologous to human CCDC134 (coiled-coil domain containing 134). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 75.9), Thymus (RPKM 56.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc134 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115526537..115539155)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113644557..113659050)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123362471..123376930)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC100362109 Neighboring gene meiotic double-stranded break formation protein 1 Neighboring gene uncharacterized LOC134479947 Neighboring gene sterol regulatory element binding transcription factor 2 Neighboring gene microRNA 33 Neighboring gene shisa family member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CCDC134 serves a crucial role in embryonic development. Yu B, et al. Int J Mol Med, 2018 Jan. PMID 29115376, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 134

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024355.1 → NP_001019526.1  coiled-coil domain-containing protein 134 precursor

      See identical proteins and their annotated locations for NP_001019526.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088206
      UniProtKB/Swiss-Prot
      Q5M862
      UniProtKB/TrEMBL
      A6HT46
      Related
      ENSRNOP00000052900.2, ENSRNOT00000056048.6
      Conserved Domains (1) summary
      pfam15002
      Location:23 → 195
      ERK-JNK_inhib; ERK and JNK pathways, inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115526537..115539155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079765.2 → XP_038935693.1  coiled-coil domain-containing protein 134 isoform X1

      Conserved Domains (1) summary
      pfam15002
      Location:4 → 95
      ERK-JNK_inhib; ERK and JNK pathways, inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M862.1 GenPept UniProtKB/Swiss-Prot:Q5M862

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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