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    Tmco4 transmembrane and coiled-coil domains 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500573, updated on 2-Nov-2024

    Summary

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    Symbol
    Tmco4provided by RGD
    Full Name
    transmembrane and coiled-coil domains 4provided by RGD
    Primary source
    RGD:1566357
    See related
    EnsemblRapid:ENSRNOG00000017401 AllianceGenome:RGD:1566357
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in membrane. Orthologous to human TMCO4 (transmembrane and coiled-coil domains 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 44.3), Adrenal (RPKM 39.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmco4 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156498506..156577967)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151216499..151294726)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157421738..157501104)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487023 Neighboring gene ring finger protein 186 Neighboring gene 5-hydroxytryptamine receptor 6 Neighboring gene uncharacterized LOC120103015 Neighboring gene NBL1, DAN family BMP antagonist

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124660

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain-containing protein 4
    Names
    rCG31182-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034949.1 → NP_001030121.1  transmembrane and coiled-coil domain-containing protein 4

      See identical proteins and their annotated locations for NP_001030121.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099755
      UniProtKB/Swiss-Prot
      Q499U8
      UniProtKB/TrEMBL
      A0A0G2K6T2
      Related
      ENSRNOP00000023431.5, ENSRNOT00000023431.7
      Conserved Domains (1) summary
      pfam05277
      Location:218 → 518
      DUF726; Protein of unknown function (DUF726)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156498506..156577967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110633.2 → XP_038966561.1  transmembrane and coiled-coil domain-containing protein 4 isoform X2

      Conserved Domains (1) summary
      cl21494
      Location:218 → 420
      Abhydrolase; alpha/beta hydrolases

    2. XM_039110634.2 → XP_038966562.1  transmembrane and coiled-coil domain-containing protein 4 isoform X3

      Conserved Domains (1) summary
      cl21494
      Location:218 → 419
      Abhydrolase; alpha/beta hydrolases

    3. XM_006239262.4 → XP_006239324.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6T2, F1LRM3
      Conserved Domains (1) summary
      pfam05277
      Location:218 → 518
      DUF726; Protein of unknown function (DUF726)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499U8.1 GenPept UniProtKB/Swiss-Prot:Q499U8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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