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    Gmeb1 glucocorticoid modulatory element binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500558, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gmeb1provided by RGD
    Official Full Name
    glucocorticoid modulatory element binding protein 1provided by RGD
    Primary source
    RGD:1563208
    See related
    EnsemblRapid:ENSRNOG00000010910 AllianceGenome:RGD:1563208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563208
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Hsp27 protein binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human GMEB1 (glucocorticoid modulatory element binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 64.6), Kidney (RPKM 45.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmeb1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149703035..149746474, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144421151..144462448, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150408075..150449252, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene opioid receptor, delta 1 Neighboring gene YTH N6-methyladenosine RNA binding protein F2 Neighboring gene U11 spliceosomal RNA Neighboring gene TATA-box binding protein associated factor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The factor binding to the glucocorticoid modulatory element of the tyrosine aminotransferase gene is a novel and ubiquitous heteromeric complex. Oshima H, et al. J Biol Chem, 1995 Sep 15. PMID 7665613
    2. Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. Jimenez-Lara AM, et al. FEBS Lett, 2000 Feb 25. PMID 10692587
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp27 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glucocorticoid modulatory element-binding protein 1
    Names
    GMEB-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109268.2 → NP_001102738.1  glucocorticoid modulatory element-binding protein 1

      See identical proteins and their annotated locations for NP_001102738.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158640
      UniProtKB/Swiss-Prot
      B0BN09, Q9QUZ8
      Related
      ENSRNOP00000014506.4, ENSRNOT00000014506.8
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149703035..149746474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110613.2 → XP_038966541.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN09, Q9QUZ8
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    2. XM_063288267.1 → XP_063144337.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN09, Q9QUZ8

    3. XM_039110614.2 → XP_038966542.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN09, Q9QUZ8
      Conserved Domains (1) summary
      pfam01342
      Location:80 → 155
      SAND; SAND domain

    4. XM_063288269.1 → XP_063144339.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN09, Q9QUZ8

    5. XM_063288268.1 → XP_063144338.1  glucocorticoid modulatory element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN09, Q9QUZ8

    6. XM_039110615.2 → XP_038966543.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUZ8.3 GenPept UniProtKB/Swiss-Prot:Q9QUZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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