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    Tut1 terminal uridylyl transferase 1, U6 snRNA-specific [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499314, updated on 2-Nov-2024

    Summary

    Official Symbol
    Tut1provided by RGD
    Official Full Name
    terminal uridylyl transferase 1, U6 snRNA-specificprovided by RGD
    Primary source
    RGD:1561043
    See related
    AllianceGenome:RGD:1561043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA binding activity; enzyme-substrate adaptor activity; and nucleotidyltransferase activity. Predicted to be involved in U6 snRNA 3'-end processing and co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in cytosol and nucleolus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in mitochondrion and nuclear speck. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 107.7), Thymus (RPKM 89.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tut1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215277802..215288869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205848691..205859767)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225151462..225162445)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EMAP like 3 Neighboring gene metastasis associated 1 family, member 2 Neighboring gene uncharacterized LOC134483968 Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene AHNAK nucleoprotein Neighboring gene ribosomal protein L7a, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125034

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA uridylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA uridylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables U6 snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in U6 snRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in U6 snRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in histone mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    speckle targeted PIP5K1A-regulated poly(A) polymerase
    Names
    RNA-binding motif protein 21
    RNA-binding protein 21
    U6 snRNA-specific terminal uridylyltransferase 1
    U6-TUTase
    star-PAP
    NP_001029073.1
    XP_063127683.1
    XP_063127685.1
    XP_063127687.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033901.1NP_001029073.1  speckle targeted PIP5K1A-regulated poly(A) polymerase

      See identical proteins and their annotated locations for NP_001029073.1

      Status: PROVISIONAL

      Source sequence(s)
      BC104695
      UniProtKB/Swiss-Prot
      Q3MHT4
      UniProtKB/TrEMBL
      A0A8I6ADU1, A6HZY1
      Conserved Domains (5) summary
      cd05402
      Location:331401
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00451
      Location:1447
      ZnF_U1; U1-like zinc finger
      COG0724
      Location:56140
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12279
      Location:54127
      RRM_TUT1; RNA recognition motif in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins
      pfam03828
      Location:491550
      PAP_assoc; Cid1 family poly A polymerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215277802..215288869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271613.1XP_063127683.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X1

    2. XM_063271615.1XP_063127685.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X2

    3. XM_063271617.1XP_063127687.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X3

    RNA

    1. XR_010056415.1 RNA Sequence